Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 100.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 396.00 | |
25 mg | In stock | $ 787.00 | |
50 mg | In stock | $ 1,180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer. |
Targets&IC50 | A549 cells:1004 nM, H23:431 nM, H1703:145 nM, EBC-1:172 nM, H1975 (EGFR):118 nM |
In vitro | OTUB1/USP8-IN-1 (10 nM-10 μM; 72 hours) inhibited the proliferation of H1975, H1703, EBC-1, H23, and A549 cells with IC50 values of 118, 145, 172, 431, and 1004 nM, respectively[1]. |
In vivo | OTUB1/USP8-IN-1 (5 mg/kg; intraperitoneal injection; QD and BID, for 2 weeks) reduced the total tumor weight and average tumor volume in BALB/c nude mice by over twofold with BID dosing[1]. |
Molecular Weight | 426.83 |
Formula | C22H16ClFN2O4 |
CAS No. | 2858800-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (70.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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OTUB1/USP8-IN-1 2858800-98-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB inhibitor inhibit