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OTUB1/USP8-IN-1

Name: OTUB1/USP8-IN-1
Brand: TargetMol
SKU: T72784
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72784Cas No. 2858800-98-1

OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.

OTUB1/USP8-IN-1

🥰Excellent

Purity: 98.59%

Catalog No. T72784Cas No. 2858800-98-1

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$787	In Stock
50 mg	$1,180	In Stock
100 mg	$1,860	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.59%

ee:100%

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COA HPLC CSFC FNMR HNMR ORP

Product Introduction

Bioactivity

Description	OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, demonstrating IC50 values of 0.17 nM for OTUB1 and 0.28 nM for USP8. OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.
Targets&IC50	H23 cells:431 nM, H1703 cells:145 nM, H1975 cells (EGFR):118 nM, EBC-1 cells:172 nM, A549 cells:1004 nM
In vitro	OTUB1/USP8-IN-1 (10 nM-10 μM; 72 hours) inhibited the proliferation of H1975, H1703, EBC-1, H23, and A549 cells with IC50 values of 118, 145, 172, 431, and 1004 nM, respectively[1].
In vivo	OTUB1/USP8-IN-1 (5 mg/kg; intraperitoneal injection; QD and BID, for 2 weeks) reduced the total tumor weight and average tumor volume in BALB/c nude mice by over twofold with BID dosing[1].

Chemical Properties

Molecular Weight	426.83
Formula	C₂₂H₁₆ClFN₂O₄
Cas No.	2858800-98-1
Smiles	O=C1C2=C(OC(=N2)C3=C(Cl)C(O[C@H]4CN(C)CC4)=CC=C3F)C(=O)C=5C1=CC=CC5
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (70.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3429 mL	11.7143 mL	23.4285 mL	117.1427 mL
5 mM	0.4686 mL	2.3429 mL	4.6857 mL	23.4285 mL
10 mM	0.2343 mL	1.1714 mL	2.3429 mL	11.7143 mL
20 mM	0.1171 mL	0.5857 mL	1.1714 mL	5.8571 mL
50 mM	0.0469 mL	0.2343 mL	0.4686 mL	2.3429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc