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Tumor/CancerTumor/CancerImmune and InflammatoryImmune and InflammatoryNeurodegenerative DiseasesNeurodegenerative DiseasesEndocrine and MetabolismEndocrine and MetabolismCardiovascular DiseasesCardiovascular DiseasesInfectious DiseasesInfectious DiseasesOrganoids and Stem CellsOrganoids and Stem Cells

Signaling Pathway / research field

Empowering numerous drug development teams

Cancer

Tumor/Cancer

Cancer is a serious disease caused by the unrestricted proliferation of cells in the body that lose normal growth control. It can occur in any part of the body, such as the lungs, breasts, colon, and skin. Cancer is one of the major threats to global health, causing millions of deaths each year and bringing profound pain and economic burdens to patients and their families. In recent years, there has been significant progress in the field of cancer treatment, especially in areas such as targeted therapy and immunotherapy. Researchers are working hard to discover new biomarkers and treatment methods to further improve treatment effectiveness.

Cancer

Immune and Inflammatory

Immune and inflammatory diseases constitute a diverse and complex array of health problems, primarily involving abnormal reactions of the immune system. These diseases include autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus, as well as conditions like asthma and allergic diseases, which are caused by the immune system's overreaction to environmental factors. The complexity of these diseases stems from their pathogenesis, involving a combination of genetic factors, environmental influences, and lifestyle choices. They pose not only a challenge to individual health but also place a significant burden on public health systems.In recent years, the medical research field has focused on deciphering and modulating the mechanisms of the immune system to develop more effective treatment methods. This includes precisely regulating immune responses, developing innovative drugs targeting specific immune pathways, and exploring new strategies for mitigating inflammatory responses.

Cancer

Neurodegenerative Diseases

Neurodegenerative diseases are a group of conditions that affect the nervous system, primarily characterized by the gradual degeneration and death of nerve cells. These diseases include Alzheimer's disease, Parkinson's disease, Huntington's disease, and others, often leading to cognitive decline, impaired motor skills, and other neurological dysfunctions. With the aging of the global population, the incidence of these diseases is gradually increasing, posing significant challenges to patients and their families. The exact causes of neurodegenerative diseases remain a focal point of scientific research. It is currently believed that genetic factors, environmental influences, and lifestyle choices may all play a role in the development of these diseases. Due to the varying symptoms and progression patterns of these diseases, research and treatment present a high level of complexity.

Cancer

Endocrine and Metabolism

Endocrine and metabolic diseases, such as diabetes, thyroid disorders, adrenal diseases, and obesity, are caused by abnormalities in endocrine gland functions or disruptions in metabolic processes. The endocrine system, which includes the thyroid, pancreas, and adrenal glands, regulates numerous physiological functions in the body by secreting hormones. These hormones directly affect the body's metabolic processes, such as the synthesis and breakdown of substances. When this balance is disrupted, it can lead to abnormal energy metabolism, severely affecting patients' daily lives and health. In recent years, research has focused on developing new therapeutic drugs for these diseases, optimizing existing hormone replacement therapies, and gaining a deeper understanding of the impact of genetic and lifestyle factors on these diseases. The goal is to improve treatment efficacy, reduce drug side effects, and enhance patients' quality of life.

Cancer

Cardiovascular Diseases

Cardiovascular diseases refer to a group of conditions affecting the heart and blood vessel system, including coronary artery disease (leading to angina and myocardial infarction), hypertension, heart failure, cerebrovascular diseases, and others. These diseases are often closely associated with impaired vascular health, such as atherosclerosis, and lifestyle factors such as unhealthy diet, lack of exercise, smoking, and excessive drinking are also major contributors. Cardiovascular diseases are one of the leading health problems worldwide and are among the primary causes of death in adults. Prevention and treatment of cardiovascular diseases require not only lifestyle changes but also play a crucial role in pharmacotherapy and surgical interventions. Researchers are dedicated to deciphering the pathogenesis of cardiovascular diseases and developing and testing new drugs and treatment strategies to more effectively address the challenges posed by these diseases.

Cancer

Infectious Diseases

Infectious diseases are illnesses caused by various pathogens such as bacteria, viruses, fungi, or parasites, and they can be transmitted through various means including air, food, water, or direct human contact. Common infectious diseases include influenza, HIV/AIDS, tuberculosis, malaria, and novel coronavirus diseases. These diseases pose a serious threat to global public health.

Cancer

Organoids and Stem Cells

Organoids are three-dimensional miniature tissue structures cultured in a laboratory environment, capable of mimicking the cellular composition, structure, and function of real organs, and have become an important tool in modern biomedical research. They play a key role in constructing disease models, drug screening, and toxicity testing. Organoids typically originate from stem cells, which can differentiate into various cell types under specific culture conditions, eventually forming organoids. As the core of this process, stem cells have remarkable self-renewal capabilities and the potential to differentiate into various cell types.

Compound Libraries

We can provide a library of over 800 small molecule compounds with diverse types, structures, sources, and scales for high-throughput screening in new drug discovery, helping drug developers discover promising compounds.

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Citation

From research institutions to leading pharmaceutical companies, our products & services empower scientists to achieve groundbreaking discoveries. Explore citations from top-tier journals that validate the quality and impact of our products.

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2025,639(8056):1-9.
STING agonist-based ER-targeting molecules boost antigen cross-presentation
2025,188(7):1858-1877.e21.
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response
2025,188(5):1297-1314.e24.
Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target
2025,188(2):371-389.
A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
2025,188(4):944-957.e19.
Squeeze pumping of lipids and insecticides by ABCH transporter
2024, 627(8002):149-156.
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
2024,187(13):3409-3426.e24.
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
2024,628(8006):E1.
An atlas of epithelial cell states and plasticity in lung adenocarcinoma
2024,632(8024):419-428.
In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution
2024,187(25):7126-7142.e20.
Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders
2024,187(20):5620-5637.e10.
A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes
2024,386(6723):eadp3252.
Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1
2023, 186(13):2929-2949.e20.
Distinct longevity mechanisms across and within species and their association with aging
2023, 624(7992):663-671.
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
2023, 624(7992):672-681.
Ligand recognition and G protein coupling of trace amine receptor TAAR1
2023, 621(7977):188-195.
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

Citation

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