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Harmine

Name: Harmine
Brand: TargetMol
SKU: T1711
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1711Cas No. 442-51-3

Alias Telepathine

Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.

Harmine

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Purity: 99.92%

Catalog No. T1711Alias TelepathineCas No. 442-51-3

Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.92%

Color:White

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COA HPLC HNMR

Product Introduction

Harmine AI Summary

Harmine exhibits a broad spectrum of bioactivity against various biological targets, demonstrating potential therapeutic applications. It shows potent inhibitory effects on several kinases, including DYRK1A (IC50 of 33.0 nM), DYRK1B (IC50 of 166.0 nM), and DYRK2 (IC50 of 1900.0 nM). The compound also inhibits CDK5/p25 with an IC50 of 20,000 nM and HASPIN with an IC50 of 590.0 nM, indicating its potential in modulating kinase-related pathways. Moreover, Harmine demonstrates significant inhibition of human MAO-A with an IC50 of 4.1 nM, suggesting its role in modulating monoamine neurotransmitter levels. Its cytotoxic activity extends to multiple cancer cell lines, including HeLa, MCF7, and A549, with varying IC50 values, thereby suggesting anticancer properties. Additionally, Harmine shows antiviral activity against SARS-CoV-2, antimalarial activity against Plasmodium falciparum, and antileishmanial effects against Leishmania species. It also indicates selectivity towards Plasmodium falciparum over human HepG2 cells, with a selectivity index of 30.0. The compound also exhibits mild inhibitory activity on GSK-3 beta (IC50 of 32100 nM) and activity against acetylcholinesterase (IC50 of 10100 nM). Furthermore, it has been shown to affect various signaling pathways, lipid modulation, and other biological processes, as evidenced by its broad range of IC50 values and bioactivity profiles. Overall, Harmine's diverse bioactivities, including potent kinase inhibition, enzyme inhibition, antiviral, antimalarial, and cytotoxic effects, make it a potential candidate for further drug development in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
Targets&IC50	5-HT2A receptor:397 nM (Ki), MAO-A:0.048 μM(Ki)
Synonyms	Telepathine

Chemical Properties

Molecular Weight	212.25
Formula	C₁₃H₁₂N₂O
Cas No.	442-51-3
Smiles	COc1ccc2c(c1)[nH]c1c(C)nccc21
Relative Density.	1.252g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.9 mg/mL (79.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7114 mL	23.5571 mL	47.1143 mL	235.5713 mL
5 mM	0.9423 mL	4.7114 mL	9.4229 mL	47.1143 mL
10 mM	0.4711 mL	2.3557 mL	4.7114 mL	23.5571 mL
20 mM	0.2356 mL	1.1779 mL	2.3557 mL	11.7786 mL
50 mM	0.0942 mL	0.4711 mL	0.9423 mL	4.7114 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc