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Litoxetine

Catalog No. T67956 CAS 86811-09-8

Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).

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Litoxetine, CAS 86811-09-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 229.00
10 mg	In stock	$ 343.00
25 mg	In stock	$ 586.00
50 mg	In stock	$ 838.00
100 mg	In stock	$ 1,160.00
500 mg	In stock	$ 2,320.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 99.12%

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Description	Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).
Targets&IC50	[3H]-DAU 6215:0.3 microM
In vitro	Litoxetine (0.3-3 microM) antagonized the high- and low-potency phases of the 5-HT curve.[1] Litoxetine (1 and 3 microM) responses to 5-MeOT were shifted to the right in a concentration-dependent manner.[1]
In vivo	Litoxetine (twice daily for 4 days), a novel specific serotonin reuptake inhibitor.[2]

Molecular Weight	241.33
Formula	C16H19NO
CAS No.	86811-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (41.44 mM)

References and Literature

1. Lucchelli A, et al. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Br J Pharmacol. 1995 ; 114(5):1017-1025. 2. Fairweather DB, et al. The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Br J Clin Pharmacol. 1995 ; 40(2):119-125. 3. Lucchelli A, et al. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundam Clin Pharmacol. 1999 ; 13(3):330-336. 4. Dmochowski RR, et al. A randomized, placebo-controlled clinical development program exploring the use of litoxetine for treating urinary incontinence. Neurourol Urodyn. 2021 ; 40(6):1515-1523.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Clinical Compound Library Bioactive Compounds Library Max

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Keywords

Litoxetine 86811-09-8 GPCR/G Protein Neuroscience 5-HT Receptor inhibitor inhibit

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