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Meloxicam

Name: Meloxicam
Brand: TargetMol
SKU: T0826
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0826Cas No. 71125-38-7

Alias Movalis, Mobic, Metacam

Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds.

Meloxicam

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Purity: 99.60%

Catalog No. T0826Alias Movalis, Mobic, MetacamCas No. 71125-38-7

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$33	In Stock	In Stock
200 mg	$45	In Stock	In Stock
500 mg	$83	-	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.60%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds.
Targets&IC50	COX-2:0.49 µM, COX-1:36.6 µM
In vitro	In horses, administration of Meloxicam significantly reduced lameness at both 8 and 24 hours post-injection and showed a tendency to decrease exudation. Compared to placebo, Meloxicam markedly inhibited the release of prostaglandin E2 and substance P in the synovial fluid 8 hours post-injection and reduced bradykinin release at 24 hours. Additionally, Meloxicam decreased average matrix metalloproteinase activity in the equine system at both 8 and 24 hours post-administration. Horses treated with Meloxicam or phenylbutazone showed improved postoperative pain and clinical outcomes compared to those treated with saline solution (SS). Meloxicam also induced a substantial infiltration of neutrophils in ischemic lesion tissues in horses. In dogs, Meloxicam significantly reduced concentrations of prostaglandin E2 in the blood and synovial fluid on days 7 and 21 post-administration, with no significant effect on thromboxane B2 (TXB2) levels in the blood or prostaglandin E2 (PGE2) concentrations in the gastric mucosa. Furthermore, Meloxicam inhibited tumor growth and pulmonary metastasis of LM-8 cells in mice.
In vivo	Meloxicam induces apoptosis in MG-63 cell cultures, concurrently upregulating both Bax mRNA and protein levels. It significantly reduces colony size in HCA-7 and Moser-S cells. While it markedly inhibits colony formation and tumor growth in HCA-7 cells, Meloxicam shows no effect on the growth of COX-2 negative HCT-116 cells. Furthermore, Meloxicam suppresses PGE(2) production, proliferation, and invasiveness, particularly in MG-63 cells expressing relatively higher levels of COX-2.
Synonyms	Movalis, Mobic, Metacam

Chemical Properties

Molecular Weight	351.40
Formula	C₁₄H₁₃N₃O₄S₂
Cas No.	71125-38-7
Smiles	CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C2=CC=CC=C2S1(=O)=O
Relative Density.	1.613 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10.64 mg/mL (30.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8458 mL	14.2288 mL	28.4576 mL	142.2880 mL
5 mM	0.5692 mL	2.8458 mL	5.6915 mL	28.4576 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	14.2288 mL
20 mM	0.1423 mL	0.7114 mL	1.4229 mL	7.1144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc