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BJE6-106

Name: BJE6-106
Brand: TargetMol
SKU: T10555
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10555Cas No. 1564249-38-2

Alias BJE6106, BJE6 106, B-106, B106, B 106

BJE6-106 (B106) is a selective PKCδ inhibitor (IC50 = 0.05 μM) with 1000-fold higher selectivity for PKCδ than PKCα (IC50 = 50 μM). BJE6-106 induces caspase-dependent apoptosis, activates the JNK pathway and H2AX, and can be used to study NRAS-mutated melanoma.

BJE6-106

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Catalog No. T10555Alias BJE6106, BJE6 106, B-106, B106, B 106Cas No. 1564249-38-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	BJE6-106 (B106) is a selective PKCδ inhibitor (IC50 = 0.05 μM) with 1000-fold higher selectivity for PKCδ than PKCα (IC50 = 50 μM). BJE6-106 induces caspase-dependent apoptosis, activates the JNK pathway and H2AX, and can be used to study NRAS-mutated melanoma.
Targets&IC50	PKCδ:0.05 μM, PKCα:50 μM
In vitro	BJE6-106 (0.2/0.5 μM; 6–24 hours) induces caspase-dependent apoptosis in SBcl2 cells, enhancing caspase 3/7 activity [1]. BJE6-106 (0.2/0.5 μM; 24–72 hours) inhibits survival of melanoma cell lines harboring NRAS mutations [1]. BJE6-106 (0.5 μM; 2–10 hours) induces JNK, MKK4, and H2AX activation in SBcl2 cells, activating the MKK4-JNK-H2AX pathway [1].
Synonyms	BJE6106, BJE6 106, B-106, B106, B 106

Chemical Properties

Molecular Weight	381.47
Formula	C₂₆H₂₃NO₂
Cas No.	1564249-38-2
Smiles	O=CC1=CC(=CC=2C=CC(OC12)(C)C)CCN3C=4C=CC=CC4C=5C=CC=CC53
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (104.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6214 mL	13.1072 mL	26.2144 mL	131.0719 mL
5 mM	0.5243 mL	2.6214 mL	5.2429 mL	26.2144 mL
10 mM	0.2621 mL	1.3107 mL	2.6214 mL	13.1072 mL
20 mM	0.1311 mL	0.6554 mL	1.3107 mL	6.5536 mL
50 mM	0.0524 mL	0.2621 mL	0.5243 mL	2.6214 mL
100 mM	0.0262 mL	0.1311 mL	0.2621 mL	1.3107 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc