BJE6-106

Name: BJE6-106
Brand: TargetMol
SKU: T10555
Rating: 4.5 (1 reviews)

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Catalog No. T10555Cas No. 1564249-38-2

Alias B106

BJE6-106 (B106) is a potent and selective PKCδ inhibitor with an IC50 of 0.05 μM, demonstrating significant selectivity over classical PKCα (IC50: 50 μM). It induces caspase-dependent apoptosis and has a tumor-specific effect.

BJE6-106

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Catalog No. T10555Alias B106Cas No. 1564249-38-2

Pack Size	Price	Availability
25 mg	$1,140	6-8 weeks
50 mg	$1,490	6-8 weeks
100 mg	$2,320	6-8 weeks
1 mL x 10 mM (in DMSO)	$365	6-8 weeks

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Product Introduction

Bioactivity

Description	BJE6-106 (B106) is a potent and selective PKCδ inhibitor with an IC50 of 0.05 μM, demonstrating significant selectivity over classical PKCα (IC50: 50 μM). It induces caspase-dependent apoptosis and has a tumor-specific effect.
Targets&IC50	PKCα:50 μM, PKCδ:0.05 μM
In vitro	BJE6-106 (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing JNK, MKK4, and H2AX activation at different times in SBcl2 cells.
Synonyms	B106

Chemical Properties

Molecular Weight	381.47
Formula	C₂₆H₂₃NO₂
Cas No.	1564249-38-2
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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