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UK-371804

Name: UK-371804
Brand: TargetMol
SKU: T3442
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3442Cas No. 256477-09-5

Alias UK371804

UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.

UK-371804

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Purity: 99.77%

Catalog No. T3442Alias UK371804Cas No. 256477-09-5

UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
2 mg	$61	In Stock	In Stock
5 mg	$110	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$341	In Stock	In Stock
50 mg	$512	In Stock	In Stock
100 mg	$743	-	In Stock
500 mg	$1,550	-	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
Targets&IC50	uPA:10 nM. (Ki)
In vitro	In the acute excision wound model in pigs, topical administration of UK-3718046 penetrates porcine wounds and inhibits exogenous uPA activity without adverse effects on wound-healing parameters.
In vivo	In vitro studies have shown that UK-3718046 is an inhibitor of exogenous uPA in human chronic wound fluid, displaying inhibitory capabilities with an IC50 of 0.89 μM.
Synonyms	UK371804

Chemical Properties

Molecular Weight	385.83
Formula	C₁₄H₁₆ClN₅O₄S
Cas No.	256477-09-5
Smiles	CC(C)(NS(=O)(=O)c1ccc2c(Cl)cnc(NC(N)=N)c2c1)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (20.73 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 0.5 mg/mL (1.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5918 mL	12.9591 mL	25.9182 mL	129.5908 mL
5 mM	0.5184 mL	2.5918 mL	5.1836 mL	25.9182 mL
10 mM	0.2592 mL	1.2959 mL	2.5918 mL	12.9591 mL
20 mM	0.1296 mL	0.6480 mL	1.2959 mL	6.4795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc