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GSK-25

🥰Excellent
Catalog No. T4488Cas No. 874119-56-9
Alias GSK25

GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).

GSK-25

GSK-25

🥰Excellent
Purity: 98.59%
Catalog No. T4488Alias GSK25Cas No. 874119-56-9
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
2 mg$54In StockIn Stock
5 mg$84In StockIn Stock
10 mg$119In StockIn Stock
25 mg$180In StockIn Stock
50 mg$286In StockIn Stock
100 mg$478-In Stock
1 mL x 10 mM (in DMSO)$96In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.59%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Targets&IC50
mTOR (p70S6K):1000nM, ROCK1:7 nM, RSK1:398 nM
SynonymsGSK25
Chemical Properties
Molecular Weight513.33
FormulaC24H16Cl2F2N6O
Cas No.874119-56-9
SmilesCC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F
Relative Density.1.57 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (116.88 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.9 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9481 mL9.7403 mL19.4806 mL97.4032 mL
5 mM0.3896 mL1.9481 mL3.8961 mL19.4806 mL
10 mM0.1948 mL0.9740 mL1.9481 mL9.7403 mL
20 mM0.0974 mL0.4870 mL0.9740 mL4.8702 mL
50 mM0.0390 mL0.1948 mL0.3896 mL1.9481 mL
100 mM0.0195 mL0.0974 mL0.1948 mL0.9740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

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Keywords

selectiveS6KinaseS6KS6 KinaseRSK1ROKROCKRibosomal S6 Kinase (RSK)Rho-kinaseRho-associated protein kinaseRho-associated kinasepressurep70S6KP450orallymTOR (p70S6K)InhibitorinhibitGSK-25GSK 25bloodbioavailable
Related Tags: buy GSK-25 | purchase GSK-25 | GSK-25 cost | order GSK-25 | GSK-25 chemical structure | GSK-25 formula | GSK-25 molecular weight
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