Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(36)

Melanocortin Receptor

Neuropeptide FF Receptor

(16)

Neuropeptide W

(7)

Neuropeptide Y Receptor

Prostaglandin Receptor

(592)

Protease-activated Receptor

Succinate Receptor 1 (SUCNR1)

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Filter HomeSignaling PathwaysGPCR/G ProteinPAFR

48740 RP

RP-55778, RP-48740, RP 55779, RP 55778

T1015993363-11-2In house

48740 RP (RP 55779) is an antagonist of platelet-activating factor.

PAFR Platelet aggregation

$375

In Stock

Size

QTY

Niranthin

TN466050656-77-4

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

Anti-infection HBV PAFR Parasite Topoisomerase

$384

In Stock

Size

QTY

Tulopafant

RP 59227

T17178116289-53-3In house

Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.

PAFR

$700

In Stock

Size

QTY

(Rac)-Modipafant

UK-74505, UK74505, UK 74505, Modipafant racemate

T28081122956-68-7In house

(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.

Anti-infection PAFR

$219

In Stock

Size

QTY

Yangambin

TN232213060-14-5

Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin also has central nervous system activity.

Calcium Channel PAFR

$126

In Stock

Size

QTY

Ginkgolide B

BN-52021

T275115291-77-7

Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.

Apoptosis Endogenous Metabolite PAFR

In Stock

Size

QTY

Cited

SDZ-62-434

SDZ62434, SDZ 62 434

T28740115621-95-9In house

SDZ-62-434, a platelet-activating factor inhibitor with antitumor activity, inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells, making it a potential candidate for studying leukemia, human xenograft colorectal cancer, and lung cancer.

PAFR Platelet aggregation

$176

In Stock

Size

QTY

CV-6209

CV6209, CV 6209

T27102100488-87-7In house

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

Cholinesterase (ChE)PAFR

$129

In Stock

Size

QTY

Apafant

WEB-2086, WEB2086, WEB 2086

T14300105219-56-5

Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.

PAFR

In Stock

Size

QTY

Zingiberen newsaponin

Zingiberensis saponin I

TN232991653-50-8

Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.

Caspase PAFR PARP

In Stock

Size

QTY

Scutellarein tetramethyl ether

4',5,6,7-Tetramethoxyflavone

TN12711168-42-9

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and demonstrates anti-inflammatory activity via the NF-κB pathway.

Antibacterial COX NF-κB NO Synthase PAFR

In Stock

Size

QTY

Cited

Foropafant

SR27417

T15338136468-36-5

Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.

PAFR Platelet aggregation

In Stock

Size

QTY

Chamigrenal

T3P285519912-84-6

β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)

COX EGFR NOS PAFR Prostaglandin Receptor

In Stock

Size

QTY

PAF C-18

PAF (C18)

T3676374389-69-8

PAF C-18 is a naturally occurring phospholipid molecule belonging to the platelet-activating factor (PAF) family, which acts as an intercellular signaling molecule involved in platelet aggregation, vasodilatation, and inflammatory responses.PAF C-18 is involved in hemostasis and thrombosis by binding to its specific G-protein-coupled receptor (PAFR) and activating.

PAFR

$126

In Stock

Size

QTY

(-)-Denudatin B

Denudatin B

TN383187402-88-8

(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.

ATPase Calcium Channel PAFR Potassium Channel

In Stock

Size

QTY

Ferulamide

4-Hydroxy-3-methoxycinnamide

TN164361012-31-5

Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.

AChR PAFR

$185

In Stock

Size

QTY

Rocepafant

LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730

T28607132579-32-9In house

Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.

PAFR Platelet aggregation

In Stock

Size

QTY

Rupatadine

UR-12592, UR12592

T36618158876-82-5

Rupatadine (UR-12592, rupatadine) is a potent and orally available dual antagonist of PAF and histamine H1 receptors with Ki values of 0.55 μM and 0.1 μM, respectively, which provides relief of allergic symptoms and anti-inflammatory properties, and is used in allergic rhinitis and chronic urticaria.

Autophagy Histamine Receptor PAFR

In Stock

Size

QTY

Cited

Dersalazine

Dersalazine Free Base

T70084188913-58-8In house

Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.

IL Receptor PAFR Platelet aggregation

$126

In Stock

Size

QTY

Rupatadine Fumarate

Rupafin, Rinialer, Alergoliber

T6242182349-12-8

Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.

Autophagy Histamine Receptor PAFR

In Stock

Size

QTY

Cedrol

T559477-53-2

Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)

Antifungal Apoptosis Caspase Cytochromes P450 PAFR

In Stock

Size

QTY

Cited

CP 96021

T10872L139401-43-7In house

CP 96021 is a group of 5-HT1 receptors and 5-HT2 receptors antagonists that have anti-inflammatory properties and are non-non-self anti-ulcer compounds for the treatment of gastrointestinal tract and respiratory asthma.

5-HT Receptor Leukotriene Receptor PAFR

In Stock

Size

QTY

PAF-AN-1

T14007115621-84-6In house

PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.

PAFR

$700

In Stock

Size

QTY

2-Acetylbenzoic acid

TMA0536577-56-0

2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis.

PAFR Prostaglandin Receptor

In Stock

Size

QTY

Go to page 1

Page of 3