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GPCR/G Protein

Cholecystokinin Receptor

Melanin-concentrating Hormone Receptor (MCHR)

(11)

Melanocortin Receptor

Neuropeptide Y Receptor

Prostaglandin Receptor

(199)

Protease-activated Receptor

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Filter HomeSignaling PathwaysGPCR/G ProteinPAFR

48740 rp

T1015993363-11-2In house

48740 RP (RP 55779) is an antagonist of platelet-activating factor.

$375

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Niranthin

TN466050656-77-4

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

$198

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Tulopafant

T17178116289-53-3In house

Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.

$700

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(Rac)-Modipafant

T28081122956-68-7In house

(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia reperfusion (I R) in the superior mesenteric artery (SMA) of the rat.

$219

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Yangambin

TN232213060-14-5

Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin also has central nervous system activity.

$126

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Ginkgolide B

T275115291-77-7

Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.

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Cited

CV-6209

T27102100488-87-7In house

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

$129

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Zingiberen newsaponin

TN232991653-50-8

Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.

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Scutellarein tetramethyl ether

TN12711168-42-9

Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and demonstrates anti-inflammatory activity via the NF-κB pathway.

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Cited

Ferulamide

TN164361012-31-5

Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.

$185

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Chamigrenal

T3P285519912-84-6

β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)

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Apafant

T14300105219-56-5

Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.

$113

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(-)-Denudatin B

TN383187402-88-8

(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.

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PAF C-18

T3676374389-69-8

PAF C-18 is a naturally occurring phospholipid molecule belonging to the platelet-activating factor (PAF) family, which acts as an intercellular signaling molecule involved in platelet aggregation, vasodilatation, and inflammatory responses.PAF C-18 is involved in hemostasis and thrombosis by binding to its specific G-protein-coupled receptor (PAFR) and activating.

$126

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Rupatadine Fumarate

T6242182349-12-8

Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF H1 antagonist with Ki of 0.55 0.1 uM.

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PAF-AN-1

T14007115621-84-6In house

PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.

$700

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6-Deoxyjacareubin

TN316116265-56-8

6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29.0 microM and can be used in studies about natural PAF receptor antagonists.

$829

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Kadsurin A

TN436799340-07-5

Kadsurin A has anti-platelet activating factor activities.

$1,098

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6-Acetyl-2,2-dimethylchroman-4-one

TN315368799-41-7

6-Acetyl-2,2-dimethylchroman-4-one and vanillin exhibit anti-platelet aggregation activity induced by arachidonic acid in vitro.

$260

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2-Hydroxy-3-methoxybenzoic acid glucose ester

TN2763172377-87-6

2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms mouse.

$460

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Futoquinol

TN165428178-92-9

Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.

$260

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Piperlotine C

TN2087886989-88-4

Piperlotine C shows potent antiplatelet aggregation activity.

$460

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Kadsulignan L

TN1815163660-06-8

Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M.

$510

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Hancinone C

TN4181111843-10-8

Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.

$670

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