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Trimipramine maleate

Name: Trimipramine maleate
Brand: TargetMol
SKU: T1045
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1045Cas No. 521-78-8

Alias Surmontil maleate

Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.

Trimipramine maleate

🥰Excellent

Purity: 99.47%

Catalog No. T1045Alias Surmontil maleateCas No. 521-78-8

Pack Size	Price	Availability
50 mg	$33	In Stock
100 mg	$47	In Stock
200 mg	$68	In Stock
500 mg	$112	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:99.47%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.
Targets&IC50	5-HT2 receptor:8.10 (pKi), sPLA2:4.66 (pKi), 5-HT1C receptor:6.39 (pKi)
Synonyms	Surmontil maleate

Chemical Properties

Molecular Weight	410.51
Formula	C₂₄H₃₀N₂O₄
Cas No.	521-78-8
Smiles	OC(=O)\C=C/C(O)=O.CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
Relative Density.	1.029g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (121.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4360 mL	12.1800 mL	24.3599 mL	121.7997 mL
5 mM	0.4872 mL	2.4360 mL	4.8720 mL	24.3599 mL
10 mM	0.2436 mL	1.2180 mL	2.4360 mL	12.1800 mL
20 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0900 mL
50 mM	0.0487 mL	0.2436 mL	0.4872 mL	2.4360 mL
100 mM	0.0244 mL	0.1218 mL	0.2436 mL	1.2180 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc