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2,4-Dihydroxybenzaldehyde

Name: 2,4-Dihydroxybenzaldehyde
Brand: TargetMol
SKU: TN7051
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7051Cas No. 95-01-2

Alias beta-Resorcylaldehyde, 4-Hydroxysalicylaldehyde, 4-Formylresorcinol

2,4-Dihydroxybenzaldehyde (4-Formylresorcinol) is a resorcinol derivative with potent antioxidant and antibacterial activity. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

2,4-Dihydroxybenzaldehyde

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Purity: 99.92%

Catalog No. TN7051Alias beta-Resorcylaldehyde, 4-Hydroxysalicylaldehyde, 4-FormylresorcinolCas No. 95-01-2

2,4-Dihydroxybenzaldehyde (4-Formylresorcinol) is a resorcinol derivative with potent antioxidant and antibacterial activity. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$36	-	In Stock
10 g	$51	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.92%

Appearance:Solid

Color:Yellow

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COA HNMR HPLC LCMS

Product Introduction

2,4-Dihydroxybenzaldehyde AI Summary

2,4-Dihydroxybenzaldehyde has shown significant bioactivity across several biological targets. It acts as an inhibitor of pieris rapae phenoloxidase with IC50 values of 4.88 µM and 204.17 µM, suggesting its potential in modulating phenoloxidase activity. The compound also demonstrates inhibitory effects on human fatty acid amide hydrolase (FAAH) at a concentration of 1 µM, resulting in a 13.4% inhibition, indicating potential modulation of the endocannabinoid system. Furthermore, 2,4-Dihydroxybenzaldehyde inhibits the PhoP region in Salmonella Typhi (IC50 of 108848.0 nM), acts as a delayed death inhibitor of the malarial parasite plastid (potency of 1651.1 nM after 96-hour incubation), and inhibits Glutaminase (GLS) with a potency of 12589.3 nM. Additionally, 2,4-Dihydroxybenzaldehyde inhibits human aromatase activity, reducing estrone levels by 91.7% using androstenedione as a substrate in 30 minutes. It also affects the mixed function oxidase system in Wistar rat liver microsomes by inhibiting aniline hydroxylase and aminopyrine demethylase activities, with IC50 values of 1400000.0 nM and 1100000.0 nM, respectively. The compound exhibits low effectiveness in inhibiting mushroom tyrosinase (IC50 > 200,000.0 nM). Notably, 2,4-Dihydroxybenzaldehyde provides protective activity against venom-induced mortality and hemorrhage from Daboia russellii and Naja kaouthia venoms in Swiss albino mice, decreasing venom LD50 values and hemolytic lesions, while increasing survival rates and coagulation activity. With a log P value of 1.19, 2,4-Dihydroxybenzaldehyde shows moderate lipophilicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2,4-Dihydroxybenzaldehyde (4-Formylresorcinol) is a resorcinol derivative with potent antioxidant and antibacterial activity. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite.
Synonyms	beta-Resorcylaldehyde, 4-Hydroxysalicylaldehyde, 4-Formylresorcinol

Chemical Properties

Molecular Weight	138.12
Formula	C₇H₆O₃
Cas No.	95-01-2
Smiles	OC1=CC(O)=C(C=O)C=C1
Relative Density.	1.409 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (362 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2401 mL	36.2004 mL	72.4008 mL	362.0041 mL
5 mM	1.4480 mL	7.2401 mL	14.4802 mL	72.4008 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL	36.2004 mL
20 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL
50 mM	0.1448 mL	0.7240 mL	1.4480 mL	7.2401 mL
100 mM	0.0724 mL	0.3620 mL	0.7240 mL	3.6200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc