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Ro 67-4853
🥰Excellent
Catalog No. T23248Cas No. 302841-89-0
Alias Ro67-4853, Ro 674853
Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
Ro 67-4853
🥰Excellent
Purity: 98.57%
Catalog No. T23248Alias Ro67-4853, Ro 674853Cas No. 302841-89-0
Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $142 | In Stock | |
| 10 mg | $208 | In Stock | |
| 25 mg | $356 | In Stock | |
| 50 mg | $527 | In Stock | |
| 100 mg | $749 | In Stock | |
| 200 mg | $987 | In Stock |
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Purity:98.57%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration. |
| Targets&IC50 | mGluR1a:7.16 (PEC50) |
| In vitro | Ro 67-4853 (1 μM) was preincubated with BHK cells stably expressing mGluR1a for 10 min before the addition of a range of glutamate concentrations. These compounds had no agonist activity at mGluR1 when added alone, but the concentration-response curve for glutamate was shifted to the left approximately 15-fold.[1] |
| Synonyms | Ro67-4853, Ro 674853 |
| Molecular Weight | 325.36 |
| Formula | C19H19NO4 |
| Cas No. | 302841-89-0 |
| Smiles | O=C(OCCCC)NC(=O)C1C=2C=CC=CC2OC=3C=CC=CC31 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMF: 10 mg/mL (30.74 mM), Sonication is recommended. DMSO: 8 mg/mL (24.59 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/DMF
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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