Shopping Cart

Your shopping cart is currently empty

Ro 67-4853

Name: Ro 67-4853
Brand: TargetMol
SKU: T23248
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T23248Cas No. 302841-89-0

Alias Ro67-4853, Ro 674853

Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.

Ro 67-4853

😃Good

Purity: 98.57%

Catalog No. T23248Alias Ro67-4853, Ro 674853Cas No. 302841-89-0

Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$142	In Stock	In Stock
10 mg	$208	In Stock	In Stock
25 mg	$356	In Stock	In Stock
50 mg	$527	In Stock	In Stock
100 mg	$749	In Stock	In Stock
200 mg	$987	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.57%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
Targets&IC50	mGluR1a:7.16 (PEC50)
In vitro	Ro 67-4853 (1 μM) was preincubated with BHK cells stably expressing mGluR1a for 10 min before the addition of a range of glutamate concentrations. These compounds had no agonist activity at mGluR1 when added alone, but the concentration-response curve for glutamate was shifted to the left approximately 15-fold.[1]
Synonyms	Ro67-4853, Ro 674853

Chemical Properties

Molecular Weight	325.36
Formula	C₁₉H₁₉NO₄
Cas No.	302841-89-0
Smiles	O=C(OCCCC)NC(=O)C1C=2C=CC=CC2OC=3C=CC=CC31
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 10 mg/mL (30.74 mM), Sonication is recommended.

DMSO: 8 mg/mL (24.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	3.0735 mL	15.3676 mL	30.7352 mL	153.6759 mL
5 mM	0.6147 mL	3.0735 mL	6.1470 mL	30.7352 mL
10 mM	0.3074 mL	1.5368 mL	3.0735 mL	15.3676 mL
20 mM	0.1537 mL	0.7684 mL	1.5368 mL	7.6838 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc