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MP7

Name: MP7
Brand: TargetMol
SKU: T12398
Price: 125 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12398Cas No. 1001409-50-2

Alias PDK1 inhibitor

MP7 (PDK1 inhibitor) is an inhibitor of phosphoinositide-dependent kinase-1 (PDK1).

MP7

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Purity: 99.89%

Catalog No. T12398Alias PDK1 inhibitorCas No. 1001409-50-2

MP7 (PDK1 inhibitor) is an inhibitor of phosphoinositide-dependent kinase-1 (PDK1).

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$110	In Stock
10 mg	Preferential	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$125	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.89%

ee:100%

Resource Download

COA HNMR FNMR CSFC LCMS

Product Introduction

Bioactivity

Description	MP7 (PDK1 inhibitor) is an inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
In vitro	MP7 are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment.
Synonyms	PDK1 inhibitor

Chemical Properties

Molecular Weight	516.5
Formula	C₂₈H₂₂F₂N₄O₄
Cas No.	1001409-50-2
Smiles	Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F
Relative Density.	1.398 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: ≥ 100 mg/mL (193.61 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9361 mL	9.6805 mL	19.3611 mL	96.8054 mL
5 mM	0.3872 mL	1.9361 mL	3.8722 mL	19.3611 mL
10 mM	0.1936 mL	0.9681 mL	1.9361 mL	9.6805 mL
20 mM	0.0968 mL	0.4840 mL	0.9681 mL	4.8403 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9361 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc