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Anti-Granzyme B Antibody (4I316)

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Catalog No. TMAY-00660

Anti-Granzyme B Antibody (4I316) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (4I316) can be used in ELISA,IHC-P.

Anti-Granzyme B Antibody (4I316)

Anti-Granzyme B Antibody (4I316)

😃Good
Catalog No. TMAY-00660
Anti-Granzyme B Antibody (4I316) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (4I316) can be used in ELISA,IHC-P.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Granzyme B Antibody (4I316) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (4I316) can be used in ELISA,IHC-P.
Ig Type
Monoclonal Mouse IgG2b
Clone
4I316
Reactivity
Human
Verified Activity
1. Immunochemical staining of human Granzyme B in human tonsil with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).

2. Immunochemical staining of human Granzyme B in human spleen with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).

3. Immunochemical staining of human Granzyme B in human lymph node with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
Application
ELISA,IHC-P
Recommended Dose
ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme B (rhGranzyme B; TMPY-00817; NP_004122.1; Met 1-Tyr 247). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundGranzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Granzyme B protein (TMPY-00817)
Antigen Species
Human
Biology Area
Serine Proteases and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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