Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anticancer activity across various cancer cell lines [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anticancer activity across various cancer cell lines [1]. |
In vitro | Compound 14h, a carbonic anhydrase inhibitor 12 at a concentration of 10 µM for 48 hours (single dose), significantly affects the specificity and the inhibitory potency across various cancer cell lines [1]. At concentrations of 2.4 µM in MCF-7 and 2.5 µM in MDA-MB-231 for the same duration, the compound induces cell cycle arrest at the G2/M phase and increases both early and late apoptotic phases relative to control untreated cells [1]. |
Molecular Weight | 640.53 |
Formula | C27H22BrN5O5S2 |
CAS No. | 2883451-38-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Carbonic anhydrase inhibitor 12 2883451-38-3 Metabolism Carbonic Anhydrase inhibitor inhibit