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SB-747651A Dihydrochloride

Name: SB-747651A Dihydrochloride
Brand: TargetMol
SKU: T9652
Price: 750 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9652Cas No. 1781882-72-1

SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibits PRK2, RSK1, p70S6K, and ROCK-II, showcasing its potential in inflammation research [1].

SB-747651A Dihydrochloride

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Purity: 98.05%

Catalog No. T9652Cas No. 1781882-72-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$157	In Stock	In Stock
10 mg	$231	In Stock	In Stock
25 mg	$388	In Stock	In Stock
50 mg	$553	In Stock	In Stock
100 mg	$750	In Stock	In Stock
500 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.05%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibits PRK2, RSK1, p70S6K, and ROCK-II, showcasing its potential in inflammation research [1].
In vitro	SB-747651A dihydrochloride (5 μM; neutrophils) modulates neutrophil behavior in response to the CXCL2 chemotactic gradient by influencing CXCL2-induced intraluminal crawling in a Mac-1-dependent manner, obstructing the movement of adherent neutrophils to optimal emigration sites. It significantly prolongs the transmigration and detachment times of neutrophils, affecting their transendothelial migration. Additionally, it slows the migration velocity of extravascular chemotaxing neutrophils without altering their directionality towards CXCL2 signals.
In vivo	SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride significantly increases neutrophil adhesion between 3.5 and 4.5 hours after CXCL2 stimulation [3]. Additionally, the same compound administered intraperitoneally (i.p.) at the same dosage enhances neutrophil extravasation by augmenting neutrophil emigration at the 3 and 4-hour marks in a mouse peritonitis model of acute inflammation [3]. Experiments were conducted on male C57BL/6N mice aged 8 to 16 weeks, confirming that a 3 mg/kg intrascrotal injection results in heightened neutrophil adhesion following CXCL2 stimulation.

Chemical Properties

Molecular Weight	415.32
Formula	C₁₆H₂₄Cl₂N₈O
Cas No.	1781882-72-1
Smiles	Cl.Cl.CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.4 mg/mL (15.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4078 mL	12.0389 mL	24.0778 mL	120.3891 mL
5 mM	0.4816 mL	2.4078 mL	4.8156 mL	24.0778 mL
10 mM	0.2408 mL	1.2039 mL	2.4078 mL	12.0389 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc