Shopping Cart
- Remove All
Your shopping cart is currently empty
DHODH-IN-12
🥰Excellent
Catalog No. T11021Cas No. 1263303-93-0
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
DHODH-IN-12
🥰Excellent
Purity: 99.53%
Catalog No. T11021Cas No. 1263303-93-0
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $70 | In Stock | |
| 5 mg | $161 | In Stock | |
| 10 mg | $237 | In Stock | |
| 25 mg | $355 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $678 | In Stock | |
| 200 mg | $915 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $131 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Questions
View MoreBatch Information
Select Batch
Purity:99.53%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07. |
| In vitro | A compound structurally related to leflunomide was designed, which contained a furan ring. Compound 12a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanoxime DHODH-IN-12. DHODH-IN-12 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the poor stereochemistry of the oxime substructure[1]. |
| Molecular Weight | 203.2 |
| Formula | C10H9N3O2 |
| Cas No. | 1263303-93-0 |
| Smiles | N(C(/C(/C#N)=N/O)=O)C1=CC=C(C)C=C1 |
| Relative Density. | 1.23 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (295.28 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy DHODH-IN-12 | purchase DHODH-IN-12 | DHODH-IN-12 cost | order DHODH-IN-12 | DHODH-IN-12 chemical structure | DHODH-IN-12 in vitro | DHODH-IN-12 formula | DHODH-IN-12 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.