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AOH1996

🥰Excellent
Catalog No. T77520Cas No. 2089314-64-5

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.

AOH1996
Other Forms of AOH1996:
13C-d3-AOH1996TMIH-0025
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AOH1996

🥰Excellent
Purity: 99.62%
Catalog No. T77520Cas No. 2089314-64-5
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$60In StockIn Stock
5 mg$147In StockIn Stock
10 mg$228In StockIn Stock
25 mg$463In StockIn Stock
50 mg$693In StockIn Stock
100 mg$986In StockIn Stock
500 mg$1,970-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.62%
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Product Introduction

Bioactivity
Description
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
Targets&IC50
KRAS (G12D):0.93 μM, PDAC cells:0.72 μM
Chemical Properties
Molecular Weight426.46
FormulaC26H22N2O4
Cas No.2089314-64-5
SmilesC(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
Relative Density.1.269 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (586.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3449 mL11.7244 mL23.4489 mL117.2443 mL
5 mM0.4690 mL2.3449 mL4.6898 mL23.4489 mL
10 mM0.2345 mL1.1724 mL2.3449 mL11.7244 mL
20 mM0.1172 mL0.5862 mL1.1724 mL5.8622 mL
50 mM0.0469 mL0.2345 mL0.4690 mL2.3449 mL
100 mM0.0234 mL0.1172 mL0.2345 mL1.1724 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PCNADNAapoptosisAOH-1996AOH1996AOH 1996
Related Tags: buy AOH1996 | purchase AOH1996 | AOH1996 cost | order AOH1996 | AOH1996 chemical structure | AOH1996 formula | AOH1996 molecular weight
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