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AOH1996

Name: AOH1996
Brand: TargetMol
SKU: T77520
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T77520 Copy Product Info

Purity: 99.62%

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AOH1996 belongs to small molecule inhibitors and is a PCNA ligand targeting transcription-replication conflicts, with oral activity, metabolic stability, and tumor selectivity. This compound induces transcription-dependent DNA double-strand breaks and apoptosis, and is used for antitumor therapy.

Cas No. 2089314-64-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$60	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$463	In Stock	In Stock
50 mg	$693	In Stock	In Stock
100 mg	$986	In Stock	In Stock
500 mg	$1,970	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.62%

Appearance:Solid

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	AOH1996 belongs to small molecule inhibitors and is a PCNA ligand targeting transcription-replication conflicts, with oral activity, metabolic stability, and tumor selectivity. This compound induces transcription-dependent DNA double-strand breaks and apoptosis, and is used for antitumor therapy.
Targets & IC50	PDAC cells:0.72 μM, KRAS (G12D):0.93 μM
In vitro	Methods: Seven AML cell lines and primary CD34+CD38- leukemic stem cells (LSC) were treated with AOH1996 at concentrations of 0.5–1 μM for 24 hours, and cell proliferation, apoptosis, and colony formation assays were performed. Results: AOH1996 dose-dependently inhibited proliferation and colony formation of AML cells and LSC, induced apoptosis, and had no significant effect on normal CD34+CD38- hematopoietic stem cells.[1]
In vivo	Methods: Human primary AML cells were transplanted into Es1(ko)SCID mice, and 7 days later, AOH1996 (100 mg/kg) was administered by oral gavage twice daily for 3 weeks. Results: AOH1996 significantly reduced leukemia burden in peripheral blood and spleen, and extended median survival from 35 days to 50 days; secondary transplantation confirmed reduced LSC burden, with survival extended from 30 days to 42 days.[1]

Chemical Properties

Molecular Weight	426.46
Formula	C₂₆H₂₂N₂O₄
Cas No.	2089314-64-5
Smiles	C(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
Relative Density.	1.269 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (586.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3449 mL	11.7244 mL	23.4489 mL	117.2443 mL
5 mM	0.4690 mL	2.3449 mL	4.6898 mL	23.4489 mL
10 mM	0.2345 mL	1.1724 mL	2.3449 mL	11.7244 mL
20 mM	0.1172 mL	0.5862 mL	1.1724 mL	5.8622 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3449 mL
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	1.1724 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc