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AOH1996

🥰Excellent
Catalog No. T77520Cas No. 2089314-64-5

AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.

AOH1996

AOH1996

🥰Excellent
Purity: 99.11%
Catalog No. T77520Cas No. 2089314-64-5
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
Pack SizePriceAvailabilityQuantity
1 mg$60In Stock
5 mg$147In Stock
10 mg$228In Stock
25 mg$463In Stock
50 mg$693In Stock
100 mg$986In Stock
500 mg$1,970In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.11%
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Product Introduction

Bioactivity
Description
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
Targets&IC50
PDAC cells:0.72 μM, KRAS (G12D):0.93 μM
Chemical Properties
Molecular Weight426.46
FormulaC26H22N2O4
Cas No.2089314-64-5
SmilesC(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
Relative Density.1.269 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (263.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3449 mL11.7244 mL23.4489 mL117.2443 mL
5 mM0.4690 mL2.3449 mL4.6898 mL23.4489 mL
10 mM0.2345 mL1.1724 mL2.3449 mL11.7244 mL
20 mM0.1172 mL0.5862 mL1.1724 mL5.8622 mL
50 mM0.0469 mL0.2345 mL0.4690 mL2.3449 mL
100 mM0.0234 mL0.1172 mL0.2345 mL1.1724 mL

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