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1-Methylimidazole

Name: 1-Methylimidazole
Brand: TargetMol
SKU: T0575
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0575Cas No. 616-47-7

1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.

1-Methylimidazole

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Purity: 99.50%

Catalog No. T0575Cas No. 616-47-7

1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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Batch Information

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Purity:99.50%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

1-Methylimidazole AI Summary

1-Methylimidazole is a multi-functional bioactive compound with diverse properties and activities. It has a dissociation constant (pKa) of 7.12, indicating specific behaviors related to ionization and protonation at certain pH levels. It enhances styrene oxide hydrolase activity at pH 8.7, with an efficiency of E100 = 0.012 M, achieving maximum enhancement at a concentration of 0.05 M. Additionally, it enhances epoxide hydrolase activity with a Log 1/E100 value of 1.94 and has a partition coefficient (logP) value of 0.28. 1-Methylimidazole also exhibits germicidal activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes at a concentration of 254 ppm with a sterilization time of over 0.5 hours. It acts as an inhibitor of CYP3A4 with an IC50 value greater than 10,000 nM, indicating its role as a retinoic acid metabolism blocking agent (RAMBA). Moreover, it demonstrates inhibitory effects on the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 21.78% at a 20 µM concentration and exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours of virus exposure. In cellular assays, 1-Methylimidazole acts as both an agonist and antagonist of the NFkB signaling pathway with a potency of 6.3 nM. It inhibits multiple enzymes including APE1, HADH2, Histone Lysine Methyltransferase G9a, FEN1, Human D2 Dopamine Receptor, and Arylsulfatase A with varying potencies from 794.3 nM to 37685.8 nM. Overall, 1-Methylimidazole shows potential in various biochemical and pharmacological applications due to its diverse bioactive properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.

Chemical Properties

Molecular Weight	82.10
Formula	C₄H₆N₂
Cas No.	616-47-7
Smiles	CN1C=CN=C1
Relative Density.	1.035 g/cm3. Temperature:20 °C.;1.017 g/cm3. Temperature:40 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (548.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	12.1803 mL	60.9013 mL	121.8027 mL	609.0134 mL
5 mM	2.4361 mL	12.1803 mL	24.3605 mL	121.8027 mL
10 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
20 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
50 mM	0.2436 mL	1.2180 mL	2.4361 mL	12.1803 mL
100 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc