CD40 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-05425

CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.

CD40 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-05425

CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.

Pack Size	Price	Availability	Quantity
100 μg	$498	7-10 days
1 mg	$3,270	7-10 days

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Product Information

Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized mCD40-Fc at 10 μg/mL (100 μL/well) can bind cynoCD40LG-Fc/Biotin .
Description	CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P27512-1
Synonyms	TRAP,Tnfrsf5,T-BAM,p50,IMD3,IGM,HIGM1,GP39,CD40 molecule, TNF receptor superfamily member 5,Bp50,AI326936
Construction	A DNA sequence encoding the mouse CD40 (NP_035741.2) (Met1-Arg193) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 20
Protein Purity	> 90 % as determined by SDS-PAGE.
Molecular Weight	46.4 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy