Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 365.00 | |
5 mg | In stock | $ 877.00 | |
10 mg | In stock | $ 1,180.00 | |
25 mg | In stock | $ 1,790.00 | |
50 mg | In stock | $ 2,390.00 | |
100 mg | In stock | $ 3,250.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 993.00 |
Description | ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA. |
Targets&IC50 | Pf:9 nM, ERG (human):33 μM, M2:2 μM, α1A:1.2 μM |
In vitro |
ZY-19489 showed the best potency (9 nM) combined with a >1,000-fold selectivity against hERG and AChE compared.[1] 12 displayed improved bioavailability (80%) as compared with its demethylated analog, 9 owing to its improved Caco2 permeability.[1] |
Molecular Weight | 465.57 |
Formula | C24H32FN9 |
CAS No. | 1821293-40-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.66 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ZY-19489 1821293-40-6 Microbiology/Virology Parasite ZY19489 ZY 19489 2,4Pyrimidinediamine,N2(4cyclopropyl5fluoro6methyl2pyridinyl)5[(3R)3,4dimethyl1piperazinyl]N4(1,5dimethyl1Hpyrazol3yl) inhibitor inhibit