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Anti-CD16a Antibody (3I481)
😃Good
Catalog No. TMAY-00739
Alias Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Anti-CD16a Antibody (3I481) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (3I481) can be used in IHC-P.
Anti-CD16a Antibody (3I481)
Anti-CD16a Antibody (3I481)
😃Good
Catalog No. TMAY-00739Alias Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Anti-CD16a Antibody (3I481) is a Mouse antibody targeting CD16a. Anti-CD16a Antibody (3I481) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
| Ig Type | Mouse IgG1 |
| Clone | 3I481 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CD16a in human spleen with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CD16a in human lung with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human CD16a in human liver with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:250-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD16a / FCGR3A (rh CD16a / FCGR3A; TMPY-00763; P08637-1; Met1-Gln208,176F). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD16a / FCGR3A protein (TMPY-00763) |
| Antigen Species | Human |
| Biology Area | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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