Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

GSK726701A

Name: GSK726701A
Brand: TargetMol
SKU: T11499
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T11499Cas No. 945721-87-9

GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

GSK726701A

Copy Product Info

😃Good

Catalog No. T11499Cas No. 945721-87-9

GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	8-10 weeks	8-10 weeks
50 mg	$2,380	8-10 weeks	8-10 weeks
100 mg	$3,100	8-10 weeks	8-10 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
In vitro	GSK726701A demonstrates high selectivity (>100-fold) for its target prostaglandin receptors (EP1-3, DP1, FP, IP, TP) and exhibits no significant activity against a broader range of other targets.
In vivo	GSK726701A exhibits robust efficacy in various animal models for both inflammatory and neuropathic pain. Demonstrating time-dependent, complete reversal of CCI-induced mechanical allodynia at a dosage of 3mg/kg, GSK726701A matches the efficacy of the clinically acclaimed gabapentin, administered at 30mg/kg. Additionally, GSK726701A possesses an ED50 value of 0.2mg/kg in the FCA acute rat model of inflammatory pain, and showcases favorable pharmacokinetics across rat, dog, and monkey studies.

Chemical Properties

Molecular Weight	423.43
Formula	C₂₄H₂₂FNO₅
Cas No.	945721-87-9
Smiles	CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC(O)=O)c(F)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc