GSK726701A

Name: GSK726701A
Brand: TargetMol
SKU: T11499
Rating: 4.5 (1 reviews)

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Catalog No. T11499Cas No. 945721-87-9

GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

GSK726701A

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Catalog No. T11499Cas No. 945721-87-9

GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	8-10 weeks	8-10 weeks
50 mg	$2,380	8-10 weeks	8-10 weeks
100 mg	$3,100	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
In vitro	GSK726701A demonstrates high selectivity (>100-fold) for its target prostaglandin receptors (EP1-3, DP1, FP, IP, TP) and exhibits no significant activity against a broader range of other targets.
In vivo	GSK726701A exhibits robust efficacy in various animal models for both inflammatory and neuropathic pain. Demonstrating time-dependent, complete reversal of CCI-induced mechanical allodynia at a dosage of 3mg/kg, GSK726701A matches the efficacy of the clinically acclaimed gabapentin, administered at 30mg/kg. Additionally, GSK726701A possesses an ED50 value of 0.2mg/kg in the FCA acute rat model of inflammatory pain, and showcases favorable pharmacokinetics across rat, dog, and monkey studies.

Chemical Properties

Molecular Weight	423.43
Formula	C₂₄H₂₂FNO₅
Cas No.	945721-87-9
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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