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BMS-986141

🥰Excellent
Catalog No. T63966Cas No. 1478711-48-6
Alias UDM-003183

BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.

BMS-986141

BMS-986141

🥰Excellent
Purity: 100%
Catalog No. T63966Alias UDM-003183Cas No. 1478711-48-6
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
Pack SizePriceAvailabilityQuantity
1 mg$645In Stock
5 mg$1,280In Stock
10 mg$1,630In Stock
25 mg$2,330In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:100%
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Product Introduction

Bioactivity
Description
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
Targets&IC50
PAR4:2.2 nM
In vitro
With an IC50 value of 2.2 nM, BMS-986141 (compound 49) inhibits platelet aggregation induced by PAR4 agonist peptide in a concentration-dependent manner, ranging from 0 to 1 μM[1].
In vivo
BMS-986141 (compound 49), administered at a dose of 0.5 mg/kg, demonstrates excellent anti-thrombotic efficacy in cynomolgus monkeys. Additionally, it shows a slight but significant prolongation of KBT (kidney bleeding time)[1][2].
AliasUDM-003183
Chemical Properties
Molecular Weight561.63
FormulaC27H23N5O5S2
Cas No.1478711-48-6
SmilesO(CC=1N=C(SC1)C2=CC=C(C(N(C)C)=O)C=C2)C3=C4C(OC(=C4)C5=CN6C(=N5)SC(OC)=N6)=CC(OC)=C3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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