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BMS-986141

Catalog No. T63966 CAS 1478711-48-6

Synonyms: UDM-003183

BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.

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BMS-986141, CAS 1478711-48-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 1,940.00
50 mg	In stock	$ 3,960.00
100 mg	In stock	$ 5,000.00

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Purity: 99.11%

Purity: 98.36%

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Description	BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
Targets&IC50	PAR4:2.2 nM
In vitro	With an IC50 value of 2.2 nM, BMS-986141 (compound 49) inhibits platelet aggregation induced by PAR4 agonist peptide in a concentration-dependent manner, ranging from 0 to 1 μM[1].
In vivo	BMS-986141 (compound 49), administered at a dose of 0.5 mg/kg, demonstrates excellent anti-thrombotic efficacy in cynomolgus monkeys. Additionally, it shows a slight but significant prolongation of KBT (kidney bleeding time)[1][2].

Synonyms	UDM-003183
Molecular Weight	561.63
Formula	C27H23N5O5S2
CAS No.	1478711-48-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. E Scott Priestley, et al. Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem. 2022 Jul 14;65(13):8843-8854. 2. P Wong, et al. Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys. European Heart Journal, Volume 41, Iss

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library

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AZ3451 TFLLR-NH2 TRAP-6 amide acetate Protease-Activated Receptor-4 FSLLRY-NH2 TFA(245329-02-6 free base) tcY-NH2 TFA(327177-34-4 free base) SCH79797 dihydrochloride I-191

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Keywords

BMS-986141 1478711-48-6 GPCR/G Protein Protease-activated Receptor UDM-003183 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.