Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-PD-1 Antibody (9O437) (Synonyms: SLEB2, PDCD1, PD-1, PD1, CD279)
Catalog No. TMAH-00865 Copy Product Info
🥰Excellent
Anti-PD-1 Antibody (9O437) is an antibody targeting PD-1. Anti-PD-1 Antibody (9O437) can be used in ELISA,IHC,WB.
Anti-PD-1 Antibody (9O437)
Copy Product Info🥰Excellent
Catalog No. TMAH-00865
Synonyms SLEB2, PDCD1, PD-1, PD1, CD279
Anti-PD-1 Antibody (9O437) is an antibody targeting PD-1. Anti-PD-1 Antibody (9O437) can be used in ELISA,IHC,WB.
Anti-PD-1 Antibody
(9O437)
(9O437)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-PD-1 Antibody (9O437) is an antibody targeting PD-1. Anti-PD-1 Antibody (9O437) can be used in ELISA,IHC,WB. |
| Synonyms | SLEB2, PDCD1, PD-1, PD1, CD279 |
| Ig Type | Rabbit IgG |
| Clone | 9O437 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: MCF-7 whole cell lysate -All lanes: PD1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 32 KDa -Observed band size: 32 kDa 2. IHC image of TMAH-00865 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PD1 |
| Antigen Species | Human |
| Gene Name | PDCD1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cell biology, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
Preview
Related Tags: buy Anti-PD-1 Antibody (9O437) | purchase Anti-PD-1 Antibody (9O437) | Anti-PD-1 Antibody (9O437) cost | order Anti-PD-1 Antibody (9O437)
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.