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Synonyms: ORW-1, ORW1, ORW 1, ORW, HHT-1, HHT1, HHT 1, ENG, endoglin, Endoglin, END, CD-105, CD105, CD 105


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $108 | 7-10 days | 7-10 days | |
| 10 µg | $169 | 7-10 days | 7-10 days | |
| 20 µg | $267 | 7-10 days | 7-10 days | |
| 50 µg | $488 | 7-10 days | 7-10 days | |
| 100 µg | $776 | 7-10 days | 7-10 days | |
| 200 µg | $1,230 | 7-10 days | 7-10 days | |
| 500 µg | $2,290 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Biotinylated Human Endoglin, His Avi Tag at 0.5 μg/ml (100 μl/well) on the streptavidin precoated plate (5 μg/ml). Dose response curve for Anti-Endoglin Antibody, hFc Tag with the EC50 of 6.8 ng/ml determined by ELISA (QC Test). |
| Description | Endoglin/CD105 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is P17813-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | P17813-1 |
| Construction | Glu26-Gly586 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 85% as determined by HPLC |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, 8% trehalose (pH 7.4). |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | ORW-1, ORW1, ORW 1, ORW, HHT-1, HHT1, HHT 1, ENG, endoglin, Endoglin, END, CD-105, CD105, CD 105 |
| Research Background | Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. |
| Molecular Weight | 63.7 kDa (Predicted); 70-80 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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