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N-Desmethyl-Apalutamide

Name: N-Desmethyl-Apalutamide
Brand: TargetMol
SKU: T12146
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12146Cas No. 1332391-11-3

Alias N-Desmethyl Apalutamide

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

N-Desmethyl-Apalutamide

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Purity: 98.6%

Catalog No. T12146Alias N-Desmethyl ApalutamideCas No. 1332391-11-3

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$273	In Stock
10 mg	$393	In Stock
25 mg	$592	In Stock
50 mg	$816	In Stock
100 mg	$1,090	In Stock
200 mg	$1,480	In Stock
1 mL x 10 mM (in DMSO)	$293	In Stock

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Batch Information

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Purity:98.6%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
Synonyms	N-Desmethyl Apalutamide

Chemical Properties

Molecular Weight	463.41
Formula	C₂₀H₁₃F₄N₅O₂S
Cas No.	1332391-11-3
Smiles	NC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C11CCC1)c1cnc(C#N)c(c1)C(F)(F)F
Relative Density.	1.65 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1579 mL	10.7896 mL	21.5792 mL	107.8958 mL
5 mM	0.4316 mL	2.1579 mL	4.3158 mL	21.5792 mL
10 mM	0.2158 mL	1.0790 mL	2.1579 mL	10.7896 mL
20 mM	0.1079 mL	0.5395 mL	1.0790 mL	5.3948 mL
50 mM	0.0432 mL	0.2158 mL	0.4316 mL	2.1579 mL
100 mM	0.0216 mL	0.1079 mL	0.2158 mL	1.0790 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc