Istaroxime

Name: Istaroxime
Brand: TargetMol
SKU: T15600
Rating: 4.5 (1 reviews)

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Catalog No. T15600Cas No. 203737-93-3

Alias PST2744

Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).

Istaroxime

😃Good

Catalog No. T15600Alias PST2744Cas No. 203737-93-3

Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,420	6-8 weeks	6-8 weeks
50 mg	$3,180	6-8 weeks	6-8 weeks
100 mg	$4,300	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
Targets&IC50	Na+, K+-ATPase:0.11 μM
In vitro	Istaroxime inhibits the Na+/K+-ATPase activity from the dog kidney (IC50: 0.43 ± 0.15 μM). Istaroxime acting as a positive inotropic compound through the inhibition of the Na+, K+-ATPase[2]. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3].
In vivo	Istaroxime (PST2744) causes a progressive to enhance in +dP/dtmax throughout the infusion. That reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3].
Synonyms	PST2744

Chemical Properties

Molecular Weight	360.49
Formula	C₂₁H₃₂N₂O₃
Cas No.	203737-93-3
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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