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Talinolol
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Catalog No. T21640Cas No. 57460-41-0
(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.
Talinolol
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Purity: 98.8%
Catalog No. T21640Cas No. 57460-41-0
(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $44 | In Stock | In Stock | |
| 10 mg | $84 | In Stock | In Stock | |
| 25 mg | $189 | In Stock | In Stock | |
| 50 mg | $328 | In Stock | In Stock | |
| 100 mg | $579 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.8%
Appearance:Solid
Color:White
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Product Introduction
Talinolol AI Summary
Talinolol exhibits diverse pharmacokinetic and bioactivity profiles across multiple experimental studies. It demonstrates toxicity in mice with LD50 values ranging from 25.0 to 1048.5 mg/kg through both intravenous and oral administration. In humans, it shows a total body clearance of 4.9 mL/min/kg and a renal clearance of 2.6 mL/min/kg, indicating renal filtration as a major elimination pathway. The hepatic clearance (CL) is recorded at 2.3 mL/min/kg, with a volume of distribution at steady state (Vdss) of 3.3 L/kg. Oral bioavailability (F_fraction) is 0.55, and the fraction absorbed (Fa) is 0.65.
Talinolol exhibits notable beta-blocking activity with an activity level of 8.96 and is involved in inhibiting various targets, including the malarial parasite plastid, Glutaminase (GLS), and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It inhibits the β1 and β2 adrenergic receptors with Ki values of 240.0 nM and 900.0 nM, respectively, and shows significant activity against the SARS-CoV-2 virus by inhibiting cytotoxicity in both Caco-2 and VERO-6 cells.
Additionally, the compound has a high efflux ratio in human Caco2 cells, indicating active efflux transport mechanisms, and displays moderate permeability from the basolateral to apical side, with an efflux ratio indicating significant interactions with transporters. The compound shows an unbound fraction in human plasma of 0.39 and demonstrates binding affinity to various targets, including β1 adrenergic receptors and soluble epoxide hydrolase.
Overall, these bioactivities and pharmacokinetic properties suggest that Talinolol has potential for further pharmacological exploration, especially in the context of its beta-blocking capabilities and antiviral activity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. |
| Molecular Weight | 363.49 |
| Formula | C20H33N3O3 |
| Cas No. | 57460-41-0 |
| Smiles | CC(C)(C)NCC(O)COC1=CC=C(NC(=O)NC2CCCCC2)C=C1 |
| Relative Density. | 1.11 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (275.11 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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