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1,5-Isoquinolinediol

🥰Excellent
Catalog No. T7042Cas No. 5154-02-9

1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

1,5-Isoquinolinediol

1,5-Isoquinolinediol

🥰Excellent
Purity: 99.21%
Catalog No. T7042Cas No. 5154-02-9
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.
Pack SizePriceAvailabilityQuantity
50 mg$45In Stock
100 mg$73In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.21%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.
Targets&IC50
PARP1:0.39 μM
Chemical Properties
Molecular Weight161.16
FormulaC9H7NO2
Cas No.5154-02-9
SmilesOc1cccc2c(O)nccc12
Relative Density.1.2480 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (6.21 mM), Sonication is recommended.
Ethanol: 20 mg/mL (124.1 mM), Sonication is recommended.
DMSO: 55 mg/mL (341.28 mM), Sonication is recommended.
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM6.2050 mL31.0251 mL62.0501 mL310.2507 mL
5 mM1.2410 mL6.2050 mL12.4100 mL62.0501 mL
Ethanol/DMSO
1mg5mg10mg50mg
10 mM0.6205 mL3.1025 mL6.2050 mL31.0251 mL
20 mM0.3103 mL1.5513 mL3.1025 mL15.5125 mL
50 mM0.1241 mL0.6205 mL1.2410 mL6.2050 mL
100 mM0.0621 mL0.3103 mL0.6205 mL3.1025 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

stressretinopathypoly ADP ribose polymerasePARP1PARPoxidativeoxidaseNADPHInhibitorinhibitdiabetic11885401,5-Isoquinolinediol1,5Isoquinolinediol1,5 Isoquinolinediol
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