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Xylometazoline hydrochloride

Name: Xylometazoline hydrochloride
Brand: TargetMol
SKU: T0042
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0042Cas No. 1218-35-5

Alias Xylometazoline HCl

Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.

Xylometazoline hydrochloride

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Purity: 99.87%

Catalog No. T0042Alias Xylometazoline HClCas No. 1218-35-5

Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.

Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.87%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.
Targets&IC50	α2C-adrenoceptor:220 nM, α1D-adrenoceptor:450 nM, α2A-adrenoceptor:980 nM, α1B-adrenoceptor:560 nM, α2B-adrenoceptor:1.7 μM (Ki), α1A-adrenoceptor:80 nM
In vitro	Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22 μM, repectively. [1]
Synonyms	Xylometazoline HCl

Chemical Properties

Molecular Weight	280.84
Formula	C₁₆H₂₄N₂·HCl
Cas No.	1218-35-5
Smiles	Cl.Cc1cc(cc(C)c1CC1=NCCN1)C(C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (56.97 mM), Sonication is recommended.

Ethanol: 52 mg/mL (185.16 mM), Sonication is recommended.

H2O: 51 mg/mL (181.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.5607 mL	17.8037 mL	35.6075 mL	178.0373 mL
5 mM	0.7121 mL	3.5607 mL	7.1215 mL	35.6075 mL
10 mM	0.3561 mL	1.7804 mL	3.5607 mL	17.8037 mL
20 mM	0.1780 mL	0.8902 mL	1.7804 mL	8.9019 mL
50 mM	0.0712 mL	0.3561 mL	0.7121 mL	3.5607 mL

H2O/Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0356 mL	0.1780 mL	0.3561 mL	1.7804 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc