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Xylometazoline hydrochloride

Name: Xylometazoline hydrochloride
Brand: TargetMol
SKU: T0042
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0042Cas No. 1218-35-5

Alias Xylometazoline HCl

Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.

Xylometazoline hydrochloride

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Purity: 99.87%

Catalog No. T0042Alias Xylometazoline HClCas No. 1218-35-5

Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Xylometazoline hydrochloride (Xylometazoline HCl) is an α-adrenoceptor agonist usually used as nasal decongestant.
Targets&IC50	α2A-adrenoceptor:980 nM, α1A-adrenoceptor:80 nM, α2C-adrenoceptor:220 nM, α1D-adrenoceptor:450 nM, α1B-adrenoceptor:560 nM, α2B-adrenoceptor:1.7 μM (Ki)
In vitro	Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22 μM, repectively. [1]
Synonyms	Xylometazoline HCl

Chemical Properties

Molecular Weight	280.84
Formula	C₁₆H₂₄N₂·HCl
Cas No.	1218-35-5
Smiles	Cl.Cc1cc(cc(C)c1CC1=NCCN1)C(C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (56.97 mM), Sonication is recommended.

Ethanol: 52 mg/mL (185.16 mM), Sonication is recommended.

H2O: 51 mg/mL (181.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.5607 mL	17.8037 mL	35.6075 mL	178.0373 mL
5 mM	0.7121 mL	3.5607 mL	7.1215 mL	35.6075 mL
10 mM	0.3561 mL	1.7804 mL	3.5607 mL	17.8037 mL
20 mM	0.1780 mL	0.8902 mL	1.7804 mL	8.9019 mL
50 mM	0.0712 mL	0.3561 mL	0.7121 mL	3.5607 mL

H2O/Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0356 mL	0.1780 mL	0.3561 mL	1.7804 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc