Ipragliflozin (L-Proline)

Name: Ipragliflozin (L-Proline)
Brand: TargetMol
SKU: T11667
Rating: 4.5 (1 reviews)

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Catalog No. T11667Cas No. 951382-34-6

Alias Ipragliflozin L-Proline

Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

Ipragliflozin (L-Proline)

😃Good

Catalog No. T11667Alias Ipragliflozin L-ProlineCas No. 951382-34-6

Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.

Pack Size	Price	Availability	Quantity
10 mg	$30	7-10 days

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Product Introduction

Bioactivity

Description	Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6.
Targets&IC50	SGLT2:2.8 nM
In vitro	Ipragliflozin selectively and potently inhibits human, rat, and mouse SGLT2 at nanomolar ranges and exhibits stability against intestinal glucosidases.
In vivo	Following oral administration, ipragliflozin demonstrates favorable pharmacokinetic properties and dose-dependently enhances urinary glucose excretion, with effects lasting over 12 hours in normal mice. This increase in urinary glucose excretion is significant at doses of 0.3 mg/kg or higher. Additionally, a single dose of ipragliflozin effectively increases urinary glucose excretion, lowers blood glucose and plasma insulin levels, and ameliorates glucose intolerance.
Synonyms	Ipragliflozin L-Proline

Chemical Properties

Molecular Weight	519.58
Formula	C₂₆H₃₀FNO₇S
Cas No.	951382-34-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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