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SOS1-IN-11

Name: SOS1-IN-11
Brand: TargetMol
SKU: T60029
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T60029 Copy Product Info

Purity: 99.4%

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SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).

SOS1-IN-11

Copy Product Info

🥰Excellent

Catalog No. T60029

SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).

Cas No. 2654741-64-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$69	-	In Stock
5 mg	$172	-	In Stock
10 mg	$298	-	In Stock
25 mg	$475	-	In Stock
50 mg	$678	-	In Stock
100 mg	$912	-	In Stock
1 mL x 10 mM (in DMSO)	$190	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.4%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

SOS1-IN-11 AI Summary

SOS1-IN-11 exhibits impressive bioactivity, characterized by a high oral bioavailability of 100% in CD-1 mice at 100 mg/kg. It displays a potent binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1, with an inhibition constant (Ki) of 0.91 nM. The compound effectively inhibits ERK phosphorylation in human MKN-1 cells, with an IC50 of 26.0 nM, indicating significant anti-cancer potential. In vivo, it leads to a 69% reduction in tumor phosphorylated ERK expression level in human MIA PaCa-2 cells at 100 mg/kg by inhibiting the RAS/MAPK pathway. While it has a moderate to high intrinsic clearance rate in human liver microsomes (114.0 mL.min-1.kg-1) and displays moderate clearance in CD-1 mice at 3 mg/kg (17.0 mL.min-1.kg-1), the hepatic extraction ratio remains low (ERH = 0.19). Additionally, it exhibits moderate inhibition of CYP3A4, with an IC50 of 640.0 nM, suggesting potential drug-drug interaction concerns..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).

Chemical Properties

Molecular Weight	431.45
Formula	C₂₂H₂₄F₃N₅O
Cas No.	2654741-64-5
Smiles	C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(c1C)C(F)(F)F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (220.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3178 mL	11.5888 mL	23.1777 mL	115.8883 mL
5 mM	0.4636 mL	2.3178 mL	4.6355 mL	23.1777 mL
10 mM	0.2318 mL	1.1589 mL	2.3178 mL	11.5888 mL
20 mM	0.1159 mL	0.5794 mL	1.1589 mL	5.7944 mL
50 mM	0.0464 mL	0.2318 mL	0.4636 mL	2.3178 mL
100 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1589 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc