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IL-18R alpha Protein, Cynomolgus, Recombinant (His)
(Synonyms: interleukin 18 receptor 1) Copy Product InfoSynonyms: interleukin 18 receptor 1
Catalog No. TMPY-00509 Copy Product Info
IL-18R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is F7H8F9.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $68 | 7-10 days | 7-10 days | |
| 10 µg | $108 | 7-10 days | 7-10 days | |
| 20 µg | $178 | 7-10 days | 7-10 days | |
| 50 µg | $359 | 7-10 days | 7-10 days | |
| 100 µg | $696 | 7-10 days | 7-10 days | |
| 200 µg | $1,060 | 7-10 days | 7-10 days | |
| 500 µg | $2,230 | 7-10 days | 7-10 days | |
| 1 mg | $4,530 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Recombinant Human IL-18R beta/IL-18RAP Protein, hFc Tag on ProA Biosensor, can bind Recombinant Cynomolgus IL-18Rα Protein, His Tag (Cat#TMPY-00509) (Premixed with Human IL-18 Protein, Tag Free, Cat#TMPY-00277) with an affinity constant of 1.26 nM as determined in BLI assay (Sartorius Octet RED384) (QC tested). |
| Description | IL-18R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is F7H8F9. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | F7H8F9 |
| Construction | A DNA sequence encoding the cynomolgus IL18R1 (F7H8F9) (Met1-Lys315) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 19 |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | interleukin 18 receptor 1 |
| Research Background | Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause. |
| Molecular Weight | 35.6 kDa (predicted); 50-56 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-18R alpha Protein, Cynomolgus, Recombinant (His) chemical structure | IL-18R alpha Protein, Cynomolgus, Recombinant (His) molecular weight
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