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GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
(Synonyms: RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15) Copy Product InfoSynonyms: RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15
Catalog No. TMPK-00197 Copy Product Info
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.88 kDa and the accession number is Q99988.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $168 | 7-10 days | 7-10 days | |
| 20 µg | $279 | 7-10 days | 7-10 days | |
| 50 µg | $552 | 7-10 days | 7-10 days | |
| 100 µg | $932 | 7-10 days | 7-10 days | |
| 200 µg | $1,680 | 7-10 days | 7-10 days | |
| 500 µg | $3,720 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human GFRAL, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human GDF15 (H202D), hFc Tag with the EC50 of 4.4ng/ml determined by ELISA. |
| Description | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 37.88 kDa and the accession number is Q99988. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | Q99988 |
| Construction | Ala197-Ile308 (H202D) |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in PBS (pH 7.4). |
| Synonyms | RG-1, PTGF-β, PTGFBPTGF-β, PTGFBPTGF-beta, PTGF-beta, PTGFB, Placental TGF-β, Placental TGF-beta, PLAB, PDF, NAG-1, MIC-1, MIC1, GDF-15, GDF15 |
| Research Background | Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. |
| Molecular Weight | 37.88 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated chemical structure | GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated molecular weight
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