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Ziprasidone hydrochloride monohydrate
🥰Excellent
Catalog No. T0031Cas No. 138982-67-9
Alias CP 88059
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Ziprasidone hydrochloride monohydrate
🥰Excellent
Purity: 99.83%
Catalog No. T0031Alias CP 88059Cas No. 138982-67-9
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $50 | In Stock | |
| 25 mg | $81 | In Stock | |
| 50 mg | $114 | In Stock |
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Purity:99.83%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
| Targets&IC50 | 5-HT1A receptor (rat):3.4 nM, D2 receptor (rat):4.8 nM, 5-HT2A:0.42 nM, 5-HT1A receptor (human):2.5 nM |
| In vitro | Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors. |
| In vivo | Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors. |
| Synonyms | CP 88059 |
| Molecular Weight | 467.12 |
| Formula | C21H21ClN4OS·HCl·H2O |
| Cas No. | 138982-67-9 |
| Smiles | O.Cl.Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4.52 mg/mL (9.68 mM), Sonication is recommended.  | |||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.14 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α2A-adrenergic receptorα1A-adrenergic receptorZiprasidone hydrochloride monohydrateZiprasidone hydrochloride MonohydrateZiprasidone HydrochlorideZiprasidone hydrochlorideSerotonin Receptorserotoninnorepinephrine transporter (NET)InhibitorinhibitHistamineReceptorHistamine ReceptorHEK-293H1 receptorDopamineReceptorDopamine ReceptorDopamineD3D2D1CP-88059CP88059CP 88059 hydrochlorideantipsychotic agentAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT75-HT65-HT2C5-HT2A5-HT1D5-HT1B5-HT1A5-HT transporter5-HT Receptor5HT Receptor
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