Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Ziprasidone hydrochloride monohydrate

🥰Excellent
Catalog No. T0031Cas No. 138982-67-9
Alias CP 88059

Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.

Ziprasidone hydrochloride monohydrate
Other Forms of Ziprasidone hydrochloride monohydrate:

Ziprasidone hydrochloride monohydrate

🥰Excellent
Purity: 99.83%
Catalog No. T0031Alias CP 88059Cas No. 138982-67-9
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$50In StockIn Stock
25 mg$81In StockIn Stock
50 mg$114In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.83%
Color:White to Red
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Targets&IC50
5-HT1A receptor (rat):3.4 nM, D2 receptor (rat):4.8 nM, 5-HT1A receptor (human):2.5 nM, 5-HT2A:0.42 nM
In vitro
Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors.
In vivo
Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors.
SynonymsCP 88059
Chemical Properties
Molecular Weight467.12
FormulaC21H21ClN4OS·HCl·H2O
Cas No.138982-67-9
SmilesO.Cl.Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.67 mg/mL (10 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.14 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1408 mL10.7039 mL21.4078 mL107.0389 mL
5 mM0.4282 mL2.1408 mL4.2816 mL21.4078 mL
10 mM0.2141 mL1.0704 mL2.1408 mL10.7039 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α2A-adrenergic receptorα1A-adrenergic receptorZiprasidone hydrochloride monohydrateZiprasidone hydrochlorideSerotonin Receptorserotoninnorepinephrine transporter (NET)InhibitorinhibitHistamineReceptorHistamine ReceptorHEK-293H1 receptorDopamineReceptorDopamine ReceptorDopamineD3D2D1CP-88059CP88059CP 88059 hydrochlorideantipsychotic agentAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT75-HT65-HT2C5-HT2A5-HT1D5-HT1B5-HT1A5-HT transporter5-HT Receptor5HT Receptor
Related Tags: buy Ziprasidone hydrochloride monohydrate | purchase Ziprasidone hydrochloride monohydrate | Ziprasidone hydrochloride monohydrate cost | order Ziprasidone hydrochloride monohydrate | Ziprasidone hydrochloride monohydrate chemical structure | Ziprasidone hydrochloride monohydrate in vivo | Ziprasidone hydrochloride monohydrate in vitro | Ziprasidone hydrochloride monohydrate formula | Ziprasidone hydrochloride monohydrate molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.