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NSC15520
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Catalog No. T81640Cas No. 730960-98-2
Alias NSC 15520
NSC15520 is a replication protein A (RPA) inhibitor that inhibits the binding of Rad9-GST and p53-GST fusion proteins to the N-terminal DNA-binding domain (DBD) of RPA, inhibits helical destabilization of double-stranded DNA (dsDNA) oligonucleotides, and can be used to study DNA damage repair.
NSC15520
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Catalog No. T81640Alias NSC 15520Cas No. 730960-98-2
NSC15520 is a replication protein A (RPA) inhibitor that inhibits the binding of Rad9-GST and p53-GST fusion proteins to the N-terminal DNA-binding domain (DBD) of RPA, inhibits helical destabilization of double-stranded DNA (dsDNA) oligonucleotides, and can be used to study DNA damage repair.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $113 | 35 days | 35 days | |
| 5 mg | $337 | 35 days | 35 days | |
| 10 mg | $395 | 35 days | 35 days | |
| 25 mg | $833 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | NSC15520 is a replication protein A (RPA) inhibitor that inhibits the binding of Rad9-GST and p53-GST fusion proteins to the N-terminal DNA-binding domain (DBD) of RPA, inhibits helical destabilization of double-stranded DNA (dsDNA) oligonucleotides, and can be used to study DNA damage repair. |
| Targets&IC50 | RPA with the GST-p53 peptide:10 μM |
| In vitro | NSC15520 blocks the interaction of RPA with the GST-p53 peptide with an IC50 of 10 μM. NSC15520 (0-400 μM, treatment for 5 min) inhibits helix destabilizing activity and also inhibits RPA binding to dsDNA 30-mer.[1] |
| Synonyms | NSC 15520 |
| Molecular Weight | 418.52 |
| Formula | C24H34O6 |
| Cas No. | 730960-98-2 |
| Smiles | O=C(O)C1C2C(=CC3(CCC4C(C(=O)O)(C)CCCC4(C)C3C2)C1C(=O)O)C(C)C |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (47.79 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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