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Anti-HAO1 Antibody (8R666)
😃Good
Catalog No. TMAY-02222
Alias hydroxyacid oxidase (glycolate oxidase) 1, HAOX1, GOX1, GOX
Anti-HAO1 Antibody (8R666) is a Rabbit antibody targeting HAO1. Anti-HAO1 Antibody (8R666) can be used in ELISA.
Anti-HAO1 Antibody (8R666)
Anti-HAO1 Antibody (8R666)
😃Good
Catalog No. TMAY-02222Alias hydroxyacid oxidase (glycolate oxidase) 1, HAOX1, GOX1, GOX
Anti-HAO1 Antibody (8R666) is a Rabbit antibody targeting HAO1. Anti-HAO1 Antibody (8R666) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | hydroxyacid oxidase (glycolate oxidase) 1, HAOX1, GOX1, GOX |
| Ig Type | Rabbit IgG |
| Clone | 8R666 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human HAO1 (rh HAO1; TMPY-01770; NP_060015.1; Leu 2-Ile 370). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Hydroxyacid oxidase 1, also known as Glycolate oxidase, HAO1, and GOX1, is a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. HAO1 / GOX1 is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with the concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 / GOX1 is a peroxisomal protein and that the C-terminal sequence SKI acts as the targeting signal. Down-regulation of HAO1 / GOX1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to an oxidative injury involving down-regulation of ROS-producing enzymes. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human HAO1 / GOX1 protein (TMPY-01770) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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