Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 218.00 | |
1 mg | 35 days | $ 397.00 |
Description | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. |
Molecular Weight | 318.45 |
Formula | C20H30O3 |
CAS No. | 596104-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 100 mg/mL
PBS (pH 7.2): 2.7 mg/mL
Ethanol: 75 mg/mL
DMSO: 20 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10410 596104-94-8 CAY-10410 CAY 10410 inhibitor inhibit