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ICSN3250 HCl
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Catalog No. T70442LCas No. 1561902-79-1
Alias ICSN3250 HCl（1561902-73-5 Free base), ICSN 3250 HCl
ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, competing with and displacing phosphatidic acid in the FRB structural domain of mTOR, thereby preventing mTOR activation and leading to cytotoxicity.
ICSN3250 HCl
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Purity: 99.60%
Catalog No. T70442LAlias ICSN3250 HCl（1561902-73-5 Free base), ICSN 3250 HClCas No. 1561902-79-1
ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, competing with and displacing phosphatidic acid in the FRB structural domain of mTOR, thereby preventing mTOR activation and leading to cytotoxicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $483 | In Stock | In Stock | |
| 10 mg | $692 | In Stock | In Stock | |
| 25 mg | $1,080 | In Stock | In Stock | |
| 50 mg | $1,460 | In Stock | In Stock | |
| 100 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.60%
Appearance:Solid
Color:Orange
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Product Introduction
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| Description | ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, competing with and displacing phosphatidic acid in the FRB structural domain of mTOR, thereby preventing mTOR activation and leading to cytotoxicity. |
| In vitro | ICSN3250 HCl was tested on multiple cancer cell lines (HCT116, U2OS, U87, K562) and normal cells (HUVEC, NHDF, HFDPC) under standard culture conditions (10–100 nmol/L, 24–72 h). Western blot, autophagy markers, and viability assays were used to assess activity. Results showed ICSN3250 HCl selective mTORC1 inhibition and cytotoxicity in cancer cells with minimal toxicity to normal cells[1]. |
| In vivo | ICSN3250 HCl (100 nmol/L, 72 h) was applied to primary colorectal cancer cells and matched fibroblasts isolated from patient tumor tissue. Cell viability and morphology were assessed microscopically. ICSN3250 HCl selectively reduced cancer cell viability without affecting normal fibroblasts[1]. |
| Synonyms | ICSN3250 HCl（1561902-73-5 Free base), ICSN 3250 HCl |
| Molecular Weight | 633.13 |
| Formula | C31H41ClN4O8 |
| Cas No. | 1561902-79-1 |
| Smiles | Cl.O=N(=O)C=1C=C(C=C(O)C1O)C2=CN(C=C2C=3C=C(O)C(O)=C(C3)N(=O)=O)CCCN4CCCCCCCCCCCC4 |
| Relative Density. | no data available |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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