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NSC745885
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Catalog No. T16354Cas No. 4219-52-7
Alias NSC-745885, NSC 745885
NSC745885 is an antitumor agent non-toxic to normal cells that downregulates EZH2 via proteasome-mediated degradation. It exhibits toxicity against multiple normal and drug-resistant cancer cell lines and may be used in studies of advanced bladder cancer and oral squamous cell carcinoma.
NSC745885
😃Good
Catalog No. T16354Alias NSC-745885, NSC 745885Cas No. 4219-52-7
NSC745885 is an antitumor agent non-toxic to normal cells that downregulates EZH2 via proteasome-mediated degradation. It exhibits toxicity against multiple normal and drug-resistant cancer cell lines and may be used in studies of advanced bladder cancer and oral squamous cell carcinoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | 6-8 weeks | 6-8 weeks | |
| 5 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | NSC745885 is an antitumor agent non-toxic to normal cells that downregulates EZH2 via proteasome-mediated degradation. It exhibits toxicity against multiple normal and drug-resistant cancer cell lines and may be used in studies of advanced bladder cancer and oral squamous cell carcinoma. |
| In vitro | NSC745885 (0.5–4 μM; 24/48/72 h) reduced SAS cell density with growth-inhibitory or pro-apoptotic effects. After 72 h treatment, IC50 = 0.85 μM. NSC745885 dose-dependently increased membranin V-positive cells [1]. NSC745885 (0.5–2 μM; 24/48 hours) dose-dependently reduced XIAP protein levels and increased protein levels in SAS cells [1]. |
| In vivo | NSC745885 (intraperitoneal; 2 mg/kg; daily; 10 days) significantly reduced tumor size compared to controls and demonstrated superior safety to Doxorubicin [1]. |
| Synonyms | NSC-745885, NSC 745885 |
| Molecular Weight | 266.27 |
| Formula | C14H6N2O2S |
| Cas No. | 4219-52-7 |
| Smiles | O=C1C=2C=CC=CC2C(=O)C=3C4=NSN=C4C=CC13 |
| Relative Density. | 1.574 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble) |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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