NSC745885

Name: NSC745885
Brand: TargetMol
SKU: T16354
Rating: 4.5 (1 reviews)

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Catalog No. T16354Cas No. 4219-52-7

NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.

NSC745885

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Catalog No. T16354Cas No. 4219-52-7

Pack Size	Price	Availability
5 mg	$239	6-8 weeks
25 mg	$766	6-8 weeks
50 mg	$996	6-8 weeks
100 mg	$1,490	6-8 weeks

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Product Introduction

Bioactivity

Description	NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities for the study of advanced bladder and oral squamous cell carcinoma (OSCC) cancers.
In vitro	NSC745885 (0.5-4 μM; 24 hours) enhances annexin V positive cells and reduces XIAP protein levels (0.5-2 μM; 24 or 48 hours) in a dose-dependent manner, significantly decreasing the densities of cultured SAS cells compared to untreated cells, with an IC50 of 0.85 μM after 72 hours’ treatment [1].
In vivo	NSC745885 (intraperitoneal injection; 2 mg/kg; once daily; 10 days) significantly reduces tumor size compared to the vehicle control and demonstrates higher safety than doxorubicin[1].

Chemical Properties

Molecular Weight	266.27
Formula	C₁₄H₆N₂O₂S
Cas No.	4219-52-7
Relative Density.	1.574 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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