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SC 53606
(Synonyms: SC53606) Copy Product Info
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Synonyms: SC53606
Catalog No. T70498 Copy Product Info
Purity: 99.26%
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SC 53606 is a potent and selective 5-HT4 receptor antagonist with a Ki value of 12.3 ± 1.17 nM. SC 53606 antagonizes the vasodilatory effects of 5-HT4 receptor-mediated carbachol-induced contraction. SC 53606 can be used in neuroscience and gastrointestinal pharmacology research.
Cas No. 151898-33-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,670 | - | In Stock | |
| 50 mg | $2,180 | 1-2 weeks | 1-2 weeks | |
| 100 mg | $2,800 | 1-2 weeks | 1-2 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.26%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SC 53606 is a potent and selective 5-HT4 receptor antagonist with a Ki value of 12.3 ± 1.17 nM. SC 53606 antagonizes the vasodilatory effects of 5-HT4 receptor-mediated carbachol-induced contraction. SC 53606 can be used in neuroscience and gastrointestinal pharmacology research. |
| In vitro | Methods: Rat distal colon tissue was placed in an Ussing chamber after the muscular layer was stripped; the tissue was pretreated with 0.2 μM TTX to eliminate neural interference; it was then pretreated with 0.03, 0.1, or 0.3 μM SC 53606 for 20 minutes; 5-HT was added in a stepwise manner at concentrations ranging from 0.1 to 100 μM, and changes in short-circuit current were recorded to plot concentration-response curves. Results: SC 53606 caused a significant concentration-dependent rightward shift in the 5-HT concentration-response curve, significantly increased the EC₅₀ of 5-HT, and competitively inhibited 5-HT-induced Cl⁻ secretion. [3] |
| Synonyms | SC53606 |
| Molecular Weight | 318.80 |
| Formula | C16H19ClN4O |
| Cas No. | 151898-33-8 |
| Smiles | C(NC[C@H]1[C@]2(N(CC1)CCC2)[H])(=O)C=3C=4N(C=C(Cl)C3)C=CN4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SC 53606 chemical structure | SC 53606 in vitro | SC 53606 formula | SC 53606 molecular weight
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