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Anti-Glypican 3/GPC3 Antibody-PE (4J109)
🥰Excellent
Catalog No. TMAY-00147P
Anti-Glypican 3/GPC3 Antibody-PE (4J109) is a PE-conjugated Rabbit antibody targeting Glypican 3/GPC3. Anti-Glypican 3/GPC3 Antibody-PE (4J109) can be used in FCM.
Anti-Glypican 3/GPC3 Antibody-PE (4J109)
Anti-Glypican 3/GPC3 Antibody-PE (4J109)
🥰Excellent
Catalog No. TMAY-00147P
Anti-Glypican 3/GPC3 Antibody-PE (4J109) is a PE-conjugated Rabbit antibody targeting Glypican 3/GPC3. Anti-Glypican 3/GPC3 Antibody-PE (4J109) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-Glypican 3/GPC3 Antibody-PE (4J109) is a PE-conjugated Rabbit antibody targeting Glypican 3/GPC3. Anti-Glypican 3/GPC3 Antibody-PE (4J109) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4J109 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human GPC3 expression on HepG2 cells. Cells were stained with PE-conjugated anti-Human GPC3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5, and it was conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue-dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceed both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5 |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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