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H3R-IN-1 Hydrochloride

Name: H3R-IN-1 Hydrochloride
Brand: TargetMol
SKU: T11531
Rating: 4.5 (1 reviews)

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Catalog No. T11531Cas No. 2319790-07-1

H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .

H3R-IN-1 Hydrochloride

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Catalog No. T11531Cas No. 2319790-07-1

H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .
In vitro	Treatment with H3R-IN-1, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC 50 =25 nM. Western blot shows a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R-IN-1, which reveals that treatment with H3R-IN-1 drives more OPCs to differentiate. H3R-IN-1 increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner [1].
In vivo	The efficacy of H3R-IN-1 in promoting remyelination in vivo is assessed using the Cuprizone/Rapamycin-induced demyelination model. Mice receive a Cuprizone diet and intraperitoneal Rapamycin injections for 5 weeks, followed by 9 days of H3R-IN-1 treatment (30 mg/kg). Cuprizone and Rapamycin induced severe demyelination in the corpus callosum and cortex, and H3R-IN-1 administration significantly increased myelin-specific Black-gold II staining density in the lesions compared to the vehicle control group [1].

Chemical Properties

Molecular Weight	377.86
Formula	C₁₉H₂₄ClN₃O₃
Cas No.	2319790-07-1
Smiles	[H]Cl.N1(C2CCC2)CCC(CC3=NC(C4=CC=C(OCO5)C5=C4)=NO3)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (66.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6465 mL	13.2324 mL	26.4648 mL	132.3241 mL
5 mM	0.5293 mL	2.6465 mL	5.2930 mL	26.4648 mL
10 mM	0.2646 mL	1.3232 mL	2.6465 mL	13.2324 mL
20 mM	0.1323 mL	0.6616 mL	1.3232 mL	6.6162 mL
50 mM	0.0529 mL	0.2646 mL	0.5293 mL	2.6465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc