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NMac1
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Catalog No. T70957Cas No. 1332290-68-2
Alias Nm23 activator 1
NMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo.
NMac1
😃Good
Purity: 99.89%
Catalog No. T70957Alias Nm23 activator 1Cas No. 1332290-68-2
NMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $330 | - | In Stock | |
| 5 mg | $783 | - | In Stock | |
| 10 mg | $1,090 | - | In Stock | |
| 25 mg | $1,670 | - | In Stock | |
| 50 mg | $2,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
ee:99.94%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo. |
| Targets&IC50 | NDPK:10.7 μM (EC50) |
| In vitro | NMac1 is a potent activator of NDPK protein, activating NDPK activity of recombinant Nm23-H1 in a dose-dependent manner with an EC50 of 10.7 μM. The morphological changes observed in MDA-MB-231 cells after treatment with NMac1 (25 μM) included substantial changes in the original height mesenchymal type (with a large number of folds) to a non-metastatic form with reduced folds and increased cell coverage. NMac1 significantly reduced invasion and migration of MDA-MB-231 cells in a dose-dependent manner without affecting their proliferation. [1] |
| In vivo | In NOD/SCID mice injected in situ with MDA-MB-231-LUS-D3H2LN cells, treatment with NMac1 (10 mg/Kg, 3 weeks) significantly inhibited breast cancer metastasis without affecting primary tumor size. [1] |
| Synonyms | Nm23 activator 1 |
| Molecular Weight | 380.48 |
| Formula | C24H28O4 |
| Cas No. | 1332290-68-2 |
| Smiles | C(=C/C1=CC(OC)=C(OC)C=C1)\C2C(C=CCC2)C3=CC(OC)=C(OC)C=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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