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BAY 73-6691 racemate

Name: BAY 73-6691 racemate
Brand: TargetMol
SKU: T10481
Rating: 4.5 (1 reviews)

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Catalog No. T10481Cas No. 794568-90-4

Alias Rac-BAY 73-6691, BAY 736691 racemate

BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.

BAY 73-6691 racemate

😃Good

Catalog No. T10481Alias Rac-BAY 73-6691, BAY 736691 racemateCas No. 794568-90-4

BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$258	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$278	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.
In vitro	The BAY 73-6691 racemate is the BAY 73-6691 racemate. Treatment with BAY 73-6691 (50, 100, 150, and 200μg/mL) attenuated the cytotoxicity and oxidative stress of Aβ25-35-induced SH-SY5Y cells. [3]
In vivo	BAY 73-6691 (1 mg/kg/ day and 5 mg/kg/ day) for 95 days. The 5/6Nx rats developed albuminuria, decreased serum creatinine clearance (Ccr), and increased serum troponin T levels. [2] In A mouse model, BAY 73-6691 (intraperitoneal injection) protected hippocampal neurons from oxidative damage induced by Aβ25-35. [3]
Synonyms	Rac-BAY 73-6691, BAY 736691 racemate

Chemical Properties

Molecular Weight	356.73
Formula	C₁₅H₁₂ClF₃N₄O
Cas No.	794568-90-4
Smiles	O=C1N=C(NC2=C1C=NN2C=3C=CC=CC3Cl)CC(C)C(F)(F)F
Relative Density.	1.52 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (224.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (14.02 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8032 mL	14.0162 mL	28.0324 mL	140.1620 mL
5 mM	0.5606 mL	2.8032 mL	5.6065 mL	28.0324 mL
10 mM	0.2803 mL	1.4016 mL	2.8032 mL	14.0162 mL
20 mM	0.1402 mL	0.7008 mL	1.4016 mL	7.0081 mL
50 mM	0.0561 mL	0.2803 mL	0.5606 mL	2.8032 mL
100 mM	0.0280 mL	0.1402 mL	0.2803 mL	1.4016 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc