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BAY 73-6691 racemate

Name: BAY 73-6691 racemate
Brand: TargetMol
SKU: T10481
Rating: 4.5 (1 reviews)

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Catalog No. T10481Cas No. 794568-90-4

Alias Rac-BAY 73-6691, BAY 736691 racemate

BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.

BAY 73-6691 racemate

Copy Product Info

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Catalog No. T10481Alias Rac-BAY 73-6691, BAY 736691 racemateCas No. 794568-90-4

BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$258	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$278	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor used for research in Parkinson's disease.
In vitro	The BAY 73-6691 racemate is the BAY 73-6691 racemate. Treatment with BAY 73-6691 (50, 100, 150, and 200μg/mL) attenuated the cytotoxicity and oxidative stress of Aβ25-35-induced SH-SY5Y cells. [3]
In vivo	BAY 73-6691 (1 mg/kg/ day and 5 mg/kg/ day) for 95 days. The 5/6Nx rats developed albuminuria, decreased serum creatinine clearance (Ccr), and increased serum troponin T levels. [2] In A mouse model, BAY 73-6691 (intraperitoneal injection) protected hippocampal neurons from oxidative damage induced by Aβ25-35. [3]
Synonyms	Rac-BAY 73-6691, BAY 736691 racemate

Chemical Properties

Molecular Weight	356.73
Formula	C₁₅H₁₂ClF₃N₄O
Cas No.	794568-90-4
Smiles	O=C1N=C(NC2=C1C=NN2C=3C=CC=CC3Cl)CC(C)C(F)(F)F
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (224.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (14.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8032 mL	14.0162 mL	28.0324 mL	140.1620 mL
5 mM	0.5606 mL	2.8032 mL	5.6065 mL	28.0324 mL
10 mM	0.2803 mL	1.4016 mL	2.8032 mL	14.0162 mL
20 mM	0.1402 mL	0.7008 mL	1.4016 mL	7.0081 mL
50 mM	0.0561 mL	0.2803 mL	0.5606 mL	2.8032 mL
100 mM	0.0280 mL	0.1402 mL	0.2803 mL	1.4016 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc