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Amodiaquine

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Catalog No. T8381Cas No. 86-42-0

Amodiaquine is a synthetic aminoquinoline, used to treat malaria.

Amodiaquine
Other Forms of Amodiaquine:

Amodiaquine

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Purity: 99.99%
Catalog No. T8381Cas No. 86-42-0
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
2 mg$64In StockIn Stock
5 mg$97In StockIn Stock
10 mg$183In StockIn Stock
25 mg$313In StockIn Stock
50 mg$438In StockIn Stock
100 mg$612In StockIn Stock
1 mL x 10 mM (in DMSO)$113In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.99%
Appearance:Solid
Color:White to Yellow
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
Targets&IC50
Nurr1-LBD (ligand binding domain):20 μM (EC50)
In vitro
Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy.
Chemical Properties
Molecular Weight355.86
FormulaC20H22ClN3O
Cas No.86-42-0
SmilesN(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN(CC)CC)=C(O)C=C3
Relative Density.1.258
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 71 mg/mL (199.52 mM), Sonication is recommended.
Methanol: 50 mg/mL (140.5 mM), Sonication is recommended.
Solution Preparation Table
Methanol/DMSO
1mg5mg10mg50mg
1 mM2.8101 mL14.0505 mL28.1009 mL140.5047 mL
5 mM0.5620 mL2.8101 mL5.6202 mL28.1009 mL
10 mM0.2810 mL1.4050 mL2.8101 mL14.0505 mL
20 mM0.1405 mL0.7025 mL1.4050 mL7.0252 mL
50 mM0.0562 mL0.2810 mL0.5620 mL2.8101 mL
100 mM0.0281 mL0.1405 mL0.2810 mL1.4050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ParasiteNurr1N-methyltransferaseneuroprotectiveInhibitorinhibitIL-1βHistoneMethyltransferaseHistone MethyltransferaseCXCL2CCL2antimalarialanti-inflammatoryAmodiaquineAmodiaquin
Related Tags: buy Amodiaquine | purchase Amodiaquine | Amodiaquine cost | order Amodiaquine | Amodiaquine chemical structure | Amodiaquine in vitro | Amodiaquine formula | Amodiaquine molecular weight
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