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Xanthoangelol

Name: Xanthoangelol
Brand: TargetMol
SKU: T13354
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13354Cas No. 62949-76-2

Xanthoangelol, which can be extracted from Angelica keiskei, inhibits obesity-induced inflammatory responses.Xanthoangelol has antimicrobial activity, inhibits monoamine oxidase, and induces apoptosis in neuroblastoma and leukemia cells.

Xanthoangelol

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Purity: 99.9%

Catalog No. T13354Cas No. 62949-76-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	-	In Stock
5 mg	$297	-	In Stock
10 mg	$455	-	In Stock
25 mg	$733	-	In Stock
50 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$368	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Xanthoangelol AI Summary

Xanthoangelol exhibits a diverse range of bioactivities targeting multiple cellular and molecular pathways. It inhibits TNF-alpha-induced NF-kappaB activation in human HeLa cells (IC50: 1030.0 nM) and LPS-induced NF-kappaB activation in mouse RAW264.7 cells (IC50: 1830.0 nM). This compound also shows superoxide-scavenging activity with an IC50 value greater than 40000.0 nM. It demonstrates cytotoxicity against human Raji cells, inhibits TPA-induced EBV-early antigen activation (IC50: 273.0 molar ratio), and scavenges NO generation in human Chang liver cells. Additionally, Xanthoangelol inhibits melanin synthesis in Normal Human Epidermal Melanocytes (NHEM) with an IC50 of 980.0 nM. In bacterial settings, it exhibits antibacterial activity against several strains, including Staphylococcus aureus (both methicillin-resistant and sensitive), Enterococcus faecalis (including vancomycin-resistant strains), Bacillus subtilis, and others, with varying MIC values. The compound also displays antiviral activity against Chikungunya virus in hamster BHK-21 cells with an EC50 of 7100.0 nM and a selectivity index of 1.7. Xanthoangelol inhibits human MAO-B selectively (IC50: 13200.0 nM) while not significantly inhibiting MAO-A. Furthermore, this compound exhibits notable cytotoxicity against human cancer cells such as K562, with an IC50 of 3980.0 nM and an apoptotic rate of 62.3% at 30 uM concentration. It shows substantial activity against Streptococcus and SK(-)GAS Group A Streptococcus with EC50 values of 1681.0 nM and 1048.0 nM, respectively, and demonstrates low toxicity against HUVEC cells (IC50 > 100000.0 nM). Lastly, Xanthoangelol induces GLUT4 translocation in rat L6 cells, implying potential effects on glucose uptake and metabolism..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	392.49
Formula	C₂₅H₂₈O₄
Cas No.	62949-76-2
Smiles	CC(C)=CCC\C(C)=C\Cc1c(O)ccc(C(=O)\C=C\c2ccc(O)cc2)c1O
Relative Density.	1.165g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (203.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5478 mL	12.7392 mL	25.4784 mL	127.3918 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL	25.4784 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL	12.7392 mL
20 mM	0.1274 mL	0.6370 mL	1.2739 mL	6.3696 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5478 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc