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Basmisanil

Name: Basmisanil
Brand: TargetMol
SKU: T7165
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7165Cas No. 1159600-41-5

Alias RO5186582, RG1662

Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.

Basmisanil

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Purity: 99.42%

Catalog No. T7165Alias RO5186582, RG1662Cas No. 1159600-41-5

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$51	In Stock
10 mg	$72	In Stock
25 mg	$125	In Stock
50 mg	$207	In Stock
100 mg	$396	In Stock
500 mg	$892	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Batch Information

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Purity:99.42%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
Synonyms	RO5186582, RG1662

Chemical Properties

Molecular Weight	445.46
Formula	C₂₁H₂₀FN₃O₅S
Cas No.	1159600-41-5
Smiles	Cc1onc(c1COc1ccc(cn1)C(=O)N1CCS(=O)(=O)CC1)-c1ccc(F)cc1
Relative Density.	1.388 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (71.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2449 mL	11.2244 mL	22.4487 mL	112.2435 mL
5 mM	0.4490 mL	2.2449 mL	4.4897 mL	22.4487 mL
10 mM	0.2245 mL	1.1224 mL	2.2449 mL	11.2244 mL
20 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6122 mL
50 mM	0.0449 mL	0.2245 mL	0.4490 mL	2.2449 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc