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B7-H3 Protein, Human, Recombinant (isoform 2, His)
(Synonyms: CD276 molecule, B7RP-2, B7-H3, B7H3, 4Ig-B7-H3) Copy Product InfoSynonyms: CD276 molecule, B7RP-2, B7-H3, B7H3, 4Ig-B7-H3
Catalog No. TMPY-06581 Copy Product Info
B7-H3 Protein, Human, Recombinant (isoform 2, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.52 kDa and the accession number is Q5ZPR3-2.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $68 | 7-10 days | 7-10 days | |
| 10 µg | $109 | 7-10 days | 7-10 days | |
| 20 µg | $172 | 7-10 days | 7-10 days | |
| 50 µg | $343 | 7-10 days | 7-10 days | |
| 100 µg | $682 | 7-10 days | 7-10 days | |
| 200 µg | $980 | 7-10 days | 7-10 days | |
| 500 µg | $1,990 | 7-10 days | 7-10 days | |
| 1 mg | $3,920 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Human B7-H3/CD276 (isoform 2) Protein (His Tag)(Cat#TMPY-06581) at 2 μg/mL(100 μL/well) can bind anti-B7-H3 (Enoblituzumab biosimilar), the EC50 is 1.0-3.0 ng/mL (QC tested). |
| Description | B7-H3 Protein, Human, Recombinant (isoform 2, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.52 kDa and the accession number is Q5ZPR3-2. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q5ZPR3-2 |
| Construction | A DNA sequence encoding the human CD276 (Q5ZPR3-2, isoform 2) (Met1-Thr243) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 29 |
| Protein Purity | > 95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | CD276 molecule, B7RP-2, B7-H3, B7H3, 4Ig-B7-H3 |
| Research Background | B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Molecular Weight | 24.52 kDa (predicted); 36.96 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: B7-H3 Protein, Human, Recombinant (isoform 2, His) chemical structure | B7-H3 Protein, Human, Recombinant (isoform 2, His) molecular weight
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